Top-down suppression deficit underlies working memory impairment in normal aging.

Journal Article (Journal Article)

In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI (functional magnetic resonance imaging), we show that healthy older adults demonstrated a prominent deficit in the suppression of cortical activity associated with task-irrelevant representations, whereas enhancement of task-relevant activity was preserved. Moreover, this suppression-specific attention deficit correlated with impaired working memory performance.

Full Text

Duke Authors

Cited Authors

  • Gazzaley, A; Cooney, JW; Rissman, J; D'Esposito, M

Published Date

  • October 2005

Published In

Volume / Issue

  • 8 / 10

Start / End Page

  • 1298 - 1300

PubMed ID

  • 16158065

Pubmed Central ID

  • 16158065

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn1543


  • eng

Conference Location

  • United States