HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Journal Article

Significance To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was HLA-DRB1*11 , which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.

Full Text

Duke Authors

Cited Authors

  • Ombrello, MJ; Remmers, EF; Tachmazidou, I; Grom, A; Foell, D; Haas, J-P; Martini, A; Gattorno, M; Özen, S; Prahalad, S; Zeft, AS; Bohnsack, JF; Mellins, ED; Ilowite, NT; Russo, R; Len, C; Hilario, MOE; Oliveira, S; Yeung, RSM; Rosenberg, A; Wedderburn, LR; Anton, J; Schwarz, T; Hinks, A; Bilginer, Y; Park, J; Cobb, J; Satorius, CL; Han, B; Baskin, E; Signa, S; Duerr, RH; Achkar, JP; Kamboh, MI; Kaufman, KM; Kottyan, LC; Pinto, D; Scherer, SW; Alarcón-Riquelme, ME; Docampo, E; Estivill, X; Gül, A; de Bakker, PIW; Raychaudhuri, S; Langefeld, CD; Thompson, S; Zeggini, E; Thomson, W; Kastner, DL; Woo, P; Allen, R; Berg, S; Bica, B; Cavalcanti, A; Chaitow, J; Cuttica, R; Duerr, R; Ellis, J; Finkel, TH; Hakonarson, H; Kaufman, K; Langefeld, C; Minden, K; Murray, K; Ozen, S; Quartier, P; Satorius, C; Schneider, R; Singh-Gerwal, D; Wulffraat, N; Abinum, M; Bell, A; Craft, AW; Crawley, E; David, J; Foster, H; Gardener-Medwin, J; Griffin, J; Hall, A; Hall, M; Herrick, AL; Hollingworth, P; Holt, L; Jones, S; Pountain, G; Ryder, C; Southwood, T; Stewart, I; Venning, H; Wyatt, S; Baildam, E; Bishop, N; Brown, L; Buckley, J; Chieng, A; Carrasco, R; Cook, L; Davidson, J; Duggan, A; Eltringham, M; Friel, E; Friswell, M; Gardner-Medwin, J; Gilbert, P; Gould, V; Hadfield, K; Hyrich, K; Jones, J; Lal, S; Lay, M; Lloyd, G; Lloyd, O; Lydon, C; Makengo, N; McGovern, A; Meijer, A; Mills-Wierda, N; Moorcroft, T; Price, V; Qiao, L; Riding, K; Sim, J; Todd, M; Tremble, S; Venter, K; Wade, D; Ward, P; Watson, S; Webster, G; Zelenovic, J; Birmingham, JD; Elder, M; Gottlieb, BS; Ilowite, NT; Imundo, LF; Kimura, Y; Lokhnygina, Y; Miller, ML; Milojevic, D; O'Neil, K; Punaro, MG; Prather, K; Ruth, NM; Sandborg, CI; Schanberg, LE; Sherry, DD; Singer, NG; Spalding, SJ; Tarvin, SE; Verbsky, JW; Wallace, CA; Zemel, LS; Burkle, K; Etheridge, A; Hirani, S; Kassoumeri, L; Melville, L; Moncrieffe, H; Mulligan, K; Newman, S; Patrick, F; Ursu, S; Whitworth, P; Baxter-Jones, A; Benseler, S; Boire, G; Cabral, DA; Cameron, B; Campillo, S; Chedeville, G; Chetaille, A-L; Dancey, P; Duffy, C; Duffy, KW; Ellsworth, J; Feldman, B; Gibbon, M; Guillet, C; Guzman, J; Houghton, K; Huber, A; Jurencak, R; Lang, B; Laxer, R; Maenz, L; Matheson, L; Oen, K; Petty, R; Ramsey, S; Rezaei, E; Roth, J; Scuccimarri, R; Silverman, E; Spiegel, L; Stringer, E; Tse, S; Tucker, LB; Turvey, S

Published Date

  • December 29, 2015

Published In

Volume / Issue

  • 112 / 52

Start / End Page

  • 15970 - 15975

Published By

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1520779112

Language

  • en