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HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Publication ,  Journal Article
Ombrello, MJ; Remmers, EF; Tachmazidou, I; Grom, A; Foell, D; Haas, J-P; Martini, A; Gattorno, M; Özen, S; Prahalad, S; Zeft, AS; Bohnsack, JF ...
Published in: Proceedings of the National Academy of Sciences
December 29, 2015

To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was, which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.

Duke Scholars

Published In

Proceedings of the National Academy of Sciences

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

December 29, 2015

Volume

112

Issue

52

Start / End Page

15970 / 15975

Publisher

Proceedings of the National Academy of Sciences
 

Citation

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Chicago
ICMJE
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Ombrello, M. J., Remmers, E. F., Tachmazidou, I., Grom, A., Foell, D., Haas, J.-P., … Turvey, S. (2015). HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proceedings of the National Academy of Sciences, 112(52), 15970–15975. https://doi.org/10.1073/pnas.1520779112
Ombrello, Michael J., Elaine F. Remmers, Ioanna Tachmazidou, Alexei Grom, Dirk Foell, Johannes-Peter Haas, Alberto Martini, et al. “HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.” Proceedings of the National Academy of Sciences 112, no. 52 (December 29, 2015): 15970–75. https://doi.org/10.1073/pnas.1520779112.
Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas J-P, et al. HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proceedings of the National Academy of Sciences. 2015 Dec 29;112(52):15970–5.
Ombrello, Michael J., et al. “HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.” Proceedings of the National Academy of Sciences, vol. 112, no. 52, Proceedings of the National Academy of Sciences, Dec. 2015, pp. 15970–75. Crossref, doi:10.1073/pnas.1520779112.
Ombrello MJ, Remmers EF, Tachmazidou I, Grom A, Foell D, Haas J-P, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Mellins ED, Ilowite NT, Russo R, Len C, Hilario MOE, Oliveira S, Yeung RSM, Rosenberg A, Wedderburn LR, Anton J, Schwarz T, Hinks A, Bilginer Y, Park J, Cobb J, Satorius CL, Han B, Baskin E, Signa S, Duerr RH, Achkar JP, Kamboh MI, Kaufman KM, Kottyan LC, Pinto D, Scherer SW, Alarcón-Riquelme ME, Docampo E, Estivill X, Gül A, de Bakker PIW, Raychaudhuri S, Langefeld CD, Thompson S, Zeggini E, Thomson W, Kastner DL, Woo P, Allen R, Berg S, Bica B, Cavalcanti A, Chaitow J, Cuttica R, Duerr R, Ellis J, Finkel TH, Hakonarson H, Kaufman K, Langefeld C, Minden K, Murray K, Ozen S, Quartier P, Satorius C, Schneider R, Singh-Gerwal D, Wulffraat N, Abinum M, Bell A, Craft AW, Crawley E, David J, Foster H, Gardener-Medwin J, Griffin J, Hall A, Hall M, Herrick AL, Hollingworth P, Holt L, Jones S, Pountain G, Ryder C, Southwood T, Stewart I, Venning H, Wyatt S, Baildam E, Bishop N, Brown L, Buckley J, Chieng A, Carrasco R, Cook L, Davidson J, Duggan A, Eltringham M, Friel E, Friswell M, Gardner-Medwin J, Gilbert P, Gould V, Hadfield K, Hyrich K, Jones J, Lal S, Lay M, Lloyd G, Lloyd O, Lydon C, Makengo N, McGovern A, Meijer A, Mills-Wierda N, Moorcroft T, Price V, Qiao L, Riding K, Sim J, Todd M, Tremble S, Venter K, Wade D, Ward P, Watson S, Webster G, Zelenovic J, Birmingham JD, Elder M, Gottlieb BS, Imundo LF, Kimura Y, Lokhnygina Y, Miller ML, Milojevic D, O’Neil K, Punaro MG, Prather K, Ruth NM, Sandborg CI, Schanberg LE, Sherry DD, Singer NG, Spalding SJ, Tarvin SE, Verbsky JW, Wallace CA, Zemel LS, Burkle K, Etheridge A, Hirani S, Kassoumeri L, Melville L, Moncrieffe H, Mulligan K, Newman S, Patrick F, Ursu S, Whitworth P, Baxter-Jones A, Benseler S, Boire G, Cabral DA, Cameron B, Campillo S, Chedeville G, Chetaille A-L, Dancey P, Duffy C, Duffy KW, Ellsworth J, Feldman B, Gibbon M, Guillet C, Guzman J, Houghton K, Huber A, Jurencak R, Lang B, Laxer R, Maenz L, Matheson L, Oen K, Petty R, Ramsey S, Rezaei E, Roth J, Scuccimarri R, Silverman E, Spiegel L, Stringer E, Tse S, Tucker LB, Turvey S. HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences; 2015 Dec 29;112(52):15970–15975.
Journal cover image

Published In

Proceedings of the National Academy of Sciences

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

December 29, 2015

Volume

112

Issue

52

Start / End Page

15970 / 15975

Publisher

Proceedings of the National Academy of Sciences