The Warburg Effect: How Does it Benefit Cancer Cells?


Journal Article (Review)

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and, together, is known as the 'Warburg Effect'. The Warburg Effect has been documented for over 90 years and extensively studied over the past 10 years, with thousands of papers reporting to have established either its causes or its functions. Despite this intense interest, the function of the Warburg Effect remains unclear. Here, we analyze several proposed explanations for the function of Warburg Effect, emphasize their rationale, and discuss their controversies.

Full Text

Duke Authors

Cited Authors

  • Liberti, MV; Locasale, JW

Published Date

  • March 2016

Published In

Volume / Issue

  • 41 / 3

Start / End Page

  • 211 - 218

PubMed ID

  • 26778478

Pubmed Central ID

  • 26778478

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2015.12.001


  • eng

Conference Location

  • England