The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.

Journal Article

T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain unclear. We describe results showing that a peptide exhibiting many hallmarks of a weak agonist stimulates T cells to proliferate more than the wild-type agonist ligand. An in silico approach suggested that the inability to form the central supramolecular activation cluster (cSMAC) could underlie the increased proliferation. This conclusion was supported by experiments that showed that enhancing cSMAC formation reduced stimulatory capacity of the weak peptide. Our studies highlight the fact that a complex interplay of factors determines the quality of a T cell antigen.

Full Text

Duke Authors

Cited Authors

  • Cemerski, S; Das, J; Locasale, J; Arnold, P; Giurisato, E; Markiewicz, MA; Fremont, D; Allen, PM; Chakraborty, AK; Shaw, AS

Published Date

  • March 8, 2007

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 345 - 355

PubMed ID

  • 17346997

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2007.01.013

Language

  • eng