Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.

Published

Journal Article

This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC).We previously described a founder mutation, MSH2*1906G >C (A636P) that causes HNPCC in 8/1345 (0.59%) of Ashkenazim with colorectal cancer. The mutation was more common in Ashkenazim diagnosed at

Full Text

Duke Authors

Cited Authors

  • Guillem, JG; Glogowski, E; Moore, HG; Nafa, K; Markowitz, AJ; Shia, J; Offit, K; Ellis, NA

Published Date

  • April 2007

Published In

Volume / Issue

  • 245 / 4

Start / End Page

  • 560 - 565

PubMed ID

  • 17414604

Pubmed Central ID

  • 17414604

Electronic International Standard Serial Number (EISSN)

  • 1528-1140

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/01.sla.0000252589.26244.d4

Language

  • eng