Concentrations of highly sensitive cardiac troponin-I predict poor cardiovascular outcomes and adverse remodeling in chronic heart failure.


Journal Article

Highly sensitive troponin (hsTn) assays may predict cardiovascular (CV) events and left ventricular (LV) remodeling in patients with heart failure (HF). In this study, 99 subjects with LV systolic dysfunction (LVSD) were followed 10 ± 3 months with serial measurement of hsTnI by a novel method. hsTnI was detectable in all subjects and was above the 99th percentile of a normal population in 56.7 %. Supramedian baseline hsTnI concentration was associated with higher-risk clinical features and shorter time-to-first event (p = 0.008). Across serial measurements, more time spent ≤ 10.9 pg/mL was associated with a lower CV event rate after adjustment (odds ratio (OR) = 0.81; p = 0.008); rising hsTnI also predicted progressive LV remodeling. In conclusion, hsTnI detected significant myocardial necrosis in a majority of patients with chronic HF due to LVSD and when measured serially, provided independent risk information for poor CV outcomes and deleterious LV remodeling.

Full Text

Duke Authors

Cited Authors

  • Motiwala, SR; Gaggin, HK; Gandhi, PU; Belcher, A; Weiner, RB; Baggish, AL; Szymonifka, J; Januzzi, JL

Published Date

  • April 2015

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 164 - 172

PubMed ID

  • 25777344

Pubmed Central ID

  • 25777344

Electronic International Standard Serial Number (EISSN)

  • 1937-5395

International Standard Serial Number (ISSN)

  • 1937-5387

Digital Object Identifier (DOI)

  • 10.1007/s12265-015-9618-4


  • eng