Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure.


Journal Article

AIM: To evaluate the associations of soluble ST2 (sST2) and galectin-3 with death relative to renal function in patients with heart failure (HF). METHODS: Eleven-hundred-and-sixty-one patients hospitalized for HF with 1-year follow up were enrolled for biomarkers analysis. RESULTS: Patients were divided into two groups based on eGFR of either > or ≤60 ml/min/1.73 m(2). sST2 was independently associated with death in both categories of renal function, while galectin-3 lost this significance after addition of NT-proBNP to the model of patients with eGFR ≤60 ml/min/1.73 m(2). CONCLUSION: In patients with HF, sST2 improved prediction for death beyond risk factors without being influenced by renal function, however, the prognostic value of galectin-3 is less clear below an eGFR of 60 ml/min/1.73 m(2).

Full Text

Duke Authors

Cited Authors

  • Zhang, R; Zhang, Y; An, T; Guo, X; Yin, S; Wang, Y; Januzzi, JL; Cappola, TP; Zhang, J

Published Date

  • 2015

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • 433 - 441

PubMed ID

  • 25985174

Pubmed Central ID

  • 25985174

Electronic International Standard Serial Number (EISSN)

  • 1752-0371

Digital Object Identifier (DOI)

  • 10.2217/bmm.15.12


  • eng

Conference Location

  • England