Biomarkers of cardiovascular stress and subclinical atherosclerosis in the community.

Published

Journal Article

Biomarkers of cardiovascular stress have been associated with incident cardiovascular outcomes. Their relations with measures of subclinical atherosclerosis, as assessed by carotid intima-media thickness, have not been well described.We measured plasma growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and high-sensitivity troponin I (hsTnI) in 3111 Framingham Offspring participants who also underwent carotid ultrasonography during the sixth examination (1995-1998, mean age 58 years, 54% women). Carotid measurements included maximal internal carotid artery (ICA) intima-media thickness (IMT), plaque presence (defined as ICA IMT >1.5 mm), and mean common carotid artery IMT. We carried out multivariable regressions for carotid measurements vs biomarkers using linear and logistic models; P < 0.0056 was deemed statistically significant.Maximal ICA IMT was significantly associated with plasma GDF-15 [β-estimate 0.04 per 1-U increase in log(GDF-15), SE 0.01, P < 0.0001]. Similarly, the odds of having carotid plaque increased 33% [odds ratio 1.33 per 1-U increase in log(GDF-15), 95% CI 1.20-1.48, P < 0.0001]. In contrast, there was no significant association of maximal ICA IMT or plaque presence with sST2 or hsTnI, and none of the 3 biomarkers was significantly associated with mean CCA IMT. GDF-15 was a stronger predictor of maximal ICA thickness and plaque presence compared with BNP and CRP when these conventional biomarkers were tested together.Increased GDF-15 concentrations are associated with subclinical atherosclerosis, including maximal ICA IMT and carotid plaque presence. Future studies investigating the role of GDF-15 for screening and management of patients with subclinical atherosclerosis are warranted.

Full Text

Duke Authors

Cited Authors

  • Gopal, DM; Larson, MG; Januzzi, JL; Cheng, S; Ghorbani, A; Wollert, KC; Kempf, T; D'Agostino, RB; Polak, JF; Ramachandran, VS; Wang, TJ; Ho, JE

Published Date

  • November 2014

Published In

Volume / Issue

  • 60 / 11

Start / End Page

  • 1402 - 1408

PubMed ID

  • 25237063

Pubmed Central ID

  • 25237063

Electronic International Standard Serial Number (EISSN)

  • 1530-8561

International Standard Serial Number (ISSN)

  • 0009-9147

Digital Object Identifier (DOI)

  • 10.1373/clinchem.2014.227116

Language

  • eng