Acute coronary syndrome antiplatelet alternatives in clopidogrel allergy.


Journal Article

No published information exists to support the safe use of ticagrelor in patients with a clopidogrel allergy. This study involved an institutional review board-approved retrospective review of patients with a documented clopidogrel allergy who subsequently received ticagrelor between July 2011 and February 2014. We report the cases of two patients with a history of hypersensitivity to clopidogrel in whom ticagrelor was used successfully without documented incident. In addition, principles suggesting a lack of cross-sensitivity between ticagrelor and clopidogrel are reviewed. These cases combined with theoretical evidence support the use of ticagrelor in patients with hypersensitivity to clopidogrel.

Full Text

Duke Authors

Cited Authors

  • Manchette, AM; Drucker, AG; Januzzi, JL

Published Date

  • August 2014

Published In

Volume / Issue

  • 34 / 8

Start / End Page

  • e152 - e156

PubMed ID

  • 24898185

Pubmed Central ID

  • 24898185

Electronic International Standard Serial Number (EISSN)

  • 1875-9114

Digital Object Identifier (DOI)

  • 10.1002/phar.1446


  • eng

Conference Location

  • United States