Extent of preoperative false lumen thrombosis does not influence long-term survival in patients with acute type A aortic dissection.

Published online

Journal Article

BACKGROUND: Partial thrombosis of the false lumen has been related to aortic growth, reoperations, and death in the chronic phase of type B and repaired type A aortic dissections. The impact of preoperative false lumen thrombosis has not been studied previously. We used data from a contemporary, multinational database on aortic dissections to evaluate whether different degrees of preoperative false lumen thrombosis influenced long-term prognosis. METHODS AND RESULTS: We examined the records of 522 patients with surgically treated acute type A aortic dissections who survived to discharge between 1996 and 2011. At the preoperative imaging, 414 (79.3%) patients had patent false lumens, 84 (16.1%) had partial thrombosis of the false lumen, and 24 (4.6%) had complete thrombosis of the false lumen. The annual median (interquartile range) aortic growth rates were 0.5 (-0.3 to 2.0) mm in the aortic arch, 2.0 (0.2 to 4.0) mm in the descending thoracic aorta, and similar regardless of the degree of false lumen thrombosis. The overall 5-year survival rate was 84.7%, and it was not influenced by false lumen thrombosis (P=0.86 by the log-rank test). Independent predictors of long-term mortality were age >70 years (hazard ratio [HR], 2.34; 95% confidence interval [CI], 1.20 to 4.56, P=0.012) and postoperative cerebrovascular accident, coma, and/or renal failure (HR, 2.62; 95% CI, 1.40 to 4.92, P=0.003). CONCLUSIONS: Patients with acute type A aortic dissection who survive to discharge have a favorable prognosis. Preoperative false lumen thrombosis does not influence long-term mortality, reintervention rates, or aortic growth.

Full Text

Duke Authors

Cited Authors

  • Larsen, M; Bartnes, K; Tsai, TT; Eagle, KA; Evangelista, A; Nienaber, CA; Suzuki, T; Fattori, R; Froehlich, JB; Hutchison, S; Sundt, TM; Januzzi, JL; Isselbacher, EM; Montgomery, DG; Myrmel, T

Published Date

  • July 1, 2013

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • e000112 -

PubMed ID

  • 23817468

Pubmed Central ID

  • 23817468

Electronic International Standard Serial Number (EISSN)

  • 2047-9980

Digital Object Identifier (DOI)

  • 10.1161/JAHA.113.000112

Language

  • eng

Conference Location

  • England