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Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation.

Publication ,  Journal Article
Rienstra, M; Yin, X; Larson, MG; Fontes, JD; Magnani, JW; McManus, DD; McCabe, EL; Coglianese, EE; Amponsah, M; Ho, JE; Januzzi, JL; Vasan, RS ...
Published in: Am Heart J
January 2014

BACKGROUND: We investigated whether circulating concentrations of soluble ST2, growth differentiation factor-15 (GDF-15), and high-sensitivity troponin I (hsTnI) are associated with incident atrial fibrillation (AF) and whether these biomarkers improve current risk prediction models including AF risk factors, B-type natriuretic peptide (BNP), and C-reactive protein (CRP). METHODS: We studied the relation between soluble ST2, GDF-15, and hsTnI and development of AF in Framingham Heart Study participants without prevalent AF. We used Cox proportional hazard regression analysis to examine the relation of incident AF during a 10-year follow-up period with each biomarker. We adjusted for standard AF clinical risk factors, BNP, and CRP. RESULTS: The mean age of the 3,217 participants was 59 ± 10 years, and 54% were women. During a 10-year follow-up, 242 participants developed AF. In age- and sex-adjusted models, GDF-15 and hsTnI were associated with risk of incident AF; however, after including the AF risk factors and BNP and CRP, only hsTnI was significantly associated with AF (hazard ratio per 1 SD of loge hsTnI, 1.12, 95% CI 1.00-1.26, P = .045). The c statistic of the base model including AF risk factors, BNP, and CRP was 0.803 (95% CI 0.777-0.830) and did not improve by adding individual or all 3 biomarkers. None of the discrimination and reclassification statistics were significant compared with the base model. CONCLUSION: In a community-based cohort, circulating hsTnI concentrations were associated with incident AF. None of the novel biomarkers evaluated improved AF risk discrimination or reclassification beyond standard clinical AF risk factors and biomarkers.

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2014

Volume

167

Issue

1

Start / End Page

109 / 115.e2

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Receptors, Cell Surface
  • Proportional Hazards Models
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans
  • Growth Differentiation Factor 15
 

Citation

APA
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ICMJE
MLA
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Rienstra, M., Yin, X., Larson, M. G., Fontes, J. D., Magnani, J. W., McManus, D. D., … Benjamin, E. J. (2014). Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation. Am Heart J, 167(1), 109-115.e2. https://doi.org/10.1016/j.ahj.2013.10.003
Rienstra, Michiel, Xiaoyan Yin, Martin G. Larson, João D. Fontes, Jared W. Magnani, David D. McManus, Elizabeth L. McCabe, et al. “Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation.Am Heart J 167, no. 1 (January 2014): 109-115.e2. https://doi.org/10.1016/j.ahj.2013.10.003.
Rienstra M, Yin X, Larson MG, Fontes JD, Magnani JW, McManus DD, et al. Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation. Am Heart J. 2014 Jan;167(1):109-115.e2.
Rienstra, Michiel, et al. “Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation.Am Heart J, vol. 167, no. 1, Jan. 2014, pp. 109-115.e2. Pubmed, doi:10.1016/j.ahj.2013.10.003.
Rienstra M, Yin X, Larson MG, Fontes JD, Magnani JW, McManus DD, McCabe EL, Coglianese EE, Amponsah M, Ho JE, Januzzi JL, Wollert KC, Fradley MG, Vasan RS, Ellinor PT, Wang TJ, Benjamin EJ. Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation. Am Heart J. 2014 Jan;167(1):109-115.e2.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2014

Volume

167

Issue

1

Start / End Page

109 / 115.e2

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Receptors, Cell Surface
  • Proportional Hazards Models
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans
  • Growth Differentiation Factor 15