Skip to main content
Journal cover image

Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy.

Publication ,  Journal Article
Shimada, YJ; Passeri, JJ; Baggish, AL; O'Callaghan, C; Lowry, PA; Yannekis, G; Abbara, S; Ghoshhajra, BB; Rothman, RD; Ho, CY; Januzzi, JL ...
Published in: JACC Heart Fail
December 2013

OBJECTIVES: The aim of this study was to evaluate the effects of losartan on left ventricular (LV) hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy (HCM). BACKGROUND: Despite evidence that myocardial hypertrophy and fibrosis are mediated by angiotensin II and are important determinants of morbidity and mortality in patients with HCM, no prior studies have evaluated the effects of angiotensin receptor blockers on LV hypertrophy and fibrosis with cardiac magnetic resonance imaging. METHODS: In double-blind fashion, 20 patients (3 women, 17 men; age: 51 ± 13 years) with HCM were randomly assigned to receive placebo (n = 9) or losartan 50 mg twice a day (n = 11) for 1 year. Cardiac magnetic resonance imaging was performed at baseline and 1 year to measure LV mass and extent of fibrosis as assessed by late gadolinium enhancement. RESULTS: There was a trend toward a significant difference in the percent change in LV mass (median [interquartile range]: +5% [-4% to +21%] with placebo vs. -5% [-11% to -0.9%] with losartan; p = 0.06). There was a significant difference in the percent change in extent of late gadolinium enhancement, with the placebo group experiencing a larger increase (+31% ± 26% with placebo vs. -23% ± 45% with losartan; p = 0.03). CONCLUSIONS: This pilot study suggests attenuation of progression of myocardial hypertrophy and fibrosis with losartan in patients with nonobstructive HCM. Confirmation of these results in a larger trial is required to confirm a place for angiotensin receptor blockers in the management of patients with HCM. (Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy; NCT01150461).

Altmetric Attention Stats
Dimensions Citation Stats

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2013

Volume

1

Issue

6

Start / End Page

480 / 487

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pilot Projects
  • Myocardium
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Losartan
  • Hypertrophy, Left Ventricular
  • Humans
  • Fibrosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shimada, Y. J., Passeri, J. J., Baggish, A. L., O’Callaghan, C., Lowry, P. A., Yannekis, G., … Fifer, M. A. (2013). Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail, 1(6), 480–487. https://doi.org/10.1016/j.jchf.2013.09.001
Shimada, Yuichi J., Jonathan J. Passeri, Aaron L. Baggish, Caitlin O’Callaghan, Patricia A. Lowry, Gia Yannekis, Suhny Abbara, et al. “Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy.JACC Heart Fail 1, no. 6 (December 2013): 480–87. https://doi.org/10.1016/j.jchf.2013.09.001.
Shimada YJ, Passeri JJ, Baggish AL, O’Callaghan C, Lowry PA, Yannekis G, et al. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2013 Dec;1(6):480–7.
Shimada, Yuichi J., et al. “Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy.JACC Heart Fail, vol. 1, no. 6, Dec. 2013, pp. 480–87. Pubmed, doi:10.1016/j.jchf.2013.09.001.
Shimada YJ, Passeri JJ, Baggish AL, O’Callaghan C, Lowry PA, Yannekis G, Abbara S, Ghoshhajra BB, Rothman RD, Ho CY, Januzzi JL, Seidman CE, Fifer MA. Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic cardiomyopathy. JACC Heart Fail. 2013 Dec;1(6):480–487.
Journal cover image

Published In

JACC Heart Fail

DOI

EISSN

2213-1787

Publication Date

December 2013

Volume

1

Issue

6

Start / End Page

480 / 487

Location

United States

Related Subject Headings

  • Prospective Studies
  • Pilot Projects
  • Myocardium
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Losartan
  • Hypertrophy, Left Ventricular
  • Humans
  • Fibrosis