Natriuretic peptides as biomarkers in heart failure.


Conference Paper

Following the initial discovery of a natriuretic and diuretic peptide factor present in atrial myocardial tissue homogenates, subsequent elucidation of the natriuretic peptide (NP) family has led to substantial advances in the understanding of the autocrine, paracrine, and endocrine regulation of the cardiovascular system. Furthermore, with the development of assays for the measurement of the NPs, these important biomarkers have gone from being regarded as biological mediators of the cardiovascular system to now represent important clinical tools for the diagnostic and prognostic evaluation of patients with heart failure and may have potential as a therapeutic target in this setting as well. An historical perspective on the NPs from bench to bedside translation will be discussed.

Full Text

Duke Authors

Cited Authors

  • Januzzi, JL

Published Date

  • August 2013

Published In

Volume / Issue

  • 61 / 6

Start / End Page

  • 950 - 955

PubMed ID

  • 23661103

Pubmed Central ID

  • 23661103

Electronic International Standard Serial Number (EISSN)

  • 1708-8267

Digital Object Identifier (DOI)

  • 10.2310/JIM.0b013e3182946b69

Conference Location

  • England