Interleukin receptor family member ST2 concentrations in patients following heart transplantation.
Published
Journal Article
OBJECTIVE: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT). METHODS: sST2 concentrations were measured in 241 patients following OHT. RESULTS: Elevated sST2 was associated with cellular rejection (CR) ≥ 1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥ 30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01). CONCLUSION: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.
Full Text
Duke Authors
Cited Authors
- Januzzi, JL; Horne, BD; Moore, SA; Galenko, O; Snow, GL; Brunisholz, KD; Muhlestein, JB; Alharethi, R; Carlquist, JF; Budge, D; Rasmussen, K; Kfoury, AG
Published Date
- May 2013
Published In
Volume / Issue
- 18 / 3
Start / End Page
- 250 - 256
PubMed ID
- 23557127
Pubmed Central ID
- 23557127
Electronic International Standard Serial Number (EISSN)
- 1366-5804
Digital Object Identifier (DOI)
- 10.3109/1354750X.2013.773081
Language
- eng
Conference Location
- England