Interleukin receptor family member ST2 concentrations in patients following heart transplantation.


Journal Article

OBJECTIVE: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT). METHODS: sST2 concentrations were measured in 241 patients following OHT. RESULTS: Elevated sST2 was associated with cellular rejection (CR) ≥ 1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥ 30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01). CONCLUSION: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.

Full Text

Duke Authors

Cited Authors

  • Januzzi, JL; Horne, BD; Moore, SA; Galenko, O; Snow, GL; Brunisholz, KD; Muhlestein, JB; Alharethi, R; Carlquist, JF; Budge, D; Rasmussen, K; Kfoury, AG

Published Date

  • May 2013

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 250 - 256

PubMed ID

  • 23557127

Pubmed Central ID

  • 23557127

Electronic International Standard Serial Number (EISSN)

  • 1366-5804

Digital Object Identifier (DOI)

  • 10.3109/1354750X.2013.773081


  • eng

Conference Location

  • England