Highly sensitive troponin T in patients with acute ischemic stroke.

Published

Journal Article

BACKGROUND: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. METHODS: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. RESULTS: A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. CONCLUSION: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.

Full Text

Duke Authors

Cited Authors

  • Jensen, JK; Ueland, T; Aukrust, P; Antonsen, L; Kristensen, SR; Januzzi, JL; Ravkilde, J

Published Date

  • 2012

Published In

Volume / Issue

  • 68 / 5

Start / End Page

  • 287 - 293

PubMed ID

  • 23051820

Pubmed Central ID

  • 23051820

Electronic International Standard Serial Number (EISSN)

  • 1421-9913

Digital Object Identifier (DOI)

  • 10.1159/000341340

Language

  • eng

Conference Location

  • Switzerland