Optimizing glycoprotein IIb/IIIa receptor antagonist use for the non-ST-segment elevation acute coronary syndromes: risk stratification and therapeutic intervention.


Journal Article (Review)

Despite extensive data supporting their use for non-ST-segment elevation acute coronary syndromes, glycoprotein (GP) IIb/IIIa antagonists are underutilized. This is likely the consequence of confusion as to which patients should receive these agents, as well as to the most appropriate timing and venue for their initiation. We will review the advances in the understanding of GP IIb/IIIa antagonist therapy, emphasizing methods of identifying those most likely to benefit from the use of GP IIb/IIIa receptor blockade. In addition, we will consider appropriate methods/venues for use of GP IIb/IIIa receptor antagonism, including its role in an "early invasive" catheterization strategy.

Full Text

Duke Authors

Cited Authors

  • Januzzi, JL; Cannon, CP; Theroux, P; Boden, WE

Published Date

  • November 2003

Published In

Volume / Issue

  • 146 / 5

Start / End Page

  • 764 - 774

PubMed ID

  • 14597924

Pubmed Central ID

  • 14597924

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/S0002-8703(03)00437-X


  • eng

Conference Location

  • United States