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Understanding amino-terminal pro-B-type natriuretic peptide in obesity.

Publication ,  Journal Article
Bayes-Genis, A; DeFilippi, C; Januzzi, JL
Published in: Am J Cardiol
February 4, 2008

Concentrations of both B-type natriuretic peptide (BNP) and its amino-terminal cleavage fragment (NT-proBNP) are relatively lower among patients with a higher body mass index (BMI). Based on data at hand, this is probably related to reduced synthesis or secretion of the peptides, rather than increased clearance (which may play only a minor role in this context). Despite this fact, age-adjusted NT-proBNP cut points to "rule in" heart failure (HF) and age-independent cut points to "rule out" HF in patients with acute dyspnea are equally useful for obese and lean patients, and no adjustment of NT-proBNP thresholds for BMI is recommended. Furthermore, the consensus-recommended NT-proBNP cut point of 1,000 ng/L for prognostication in acute dyspnea is equally useful across all BMI categories, without the need for further adjustment for weight. Thus, despite the BMI-related NP handicap observed in overweight and obese patients, NT-proBNP remains powerfully useful for diagnostic and prognostic evaluation across the entire range of BMI values.

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

February 4, 2008

Volume

101

Issue

3A

Start / End Page

89 / 94

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Protein Precursors
  • Prognosis
  • Peptide Fragments
  • Obesity
  • Natriuretic Peptide, Brain
  • Humans
  • Cardiovascular System & Hematology
  • Body Mass Index
  • Biomarkers
 

Citation

APA
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ICMJE
MLA
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Bayes-Genis, A., DeFilippi, C., & Januzzi, J. L. (2008). Understanding amino-terminal pro-B-type natriuretic peptide in obesity. Am J Cardiol, 101(3A), 89–94. https://doi.org/10.1016/j.amjcard.2007.11.030
Bayes-Genis, Antoni, Christopher DeFilippi, and James L. Januzzi. “Understanding amino-terminal pro-B-type natriuretic peptide in obesity.Am J Cardiol 101, no. 3A (February 4, 2008): 89–94. https://doi.org/10.1016/j.amjcard.2007.11.030.
Bayes-Genis A, DeFilippi C, Januzzi JL. Understanding amino-terminal pro-B-type natriuretic peptide in obesity. Am J Cardiol. 2008 Feb 4;101(3A):89–94.
Bayes-Genis, Antoni, et al. “Understanding amino-terminal pro-B-type natriuretic peptide in obesity.Am J Cardiol, vol. 101, no. 3A, Feb. 2008, pp. 89–94. Pubmed, doi:10.1016/j.amjcard.2007.11.030.
Bayes-Genis A, DeFilippi C, Januzzi JL. Understanding amino-terminal pro-B-type natriuretic peptide in obesity. Am J Cardiol. 2008 Feb 4;101(3A):89–94.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

February 4, 2008

Volume

101

Issue

3A

Start / End Page

89 / 94

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Protein Precursors
  • Prognosis
  • Peptide Fragments
  • Obesity
  • Natriuretic Peptide, Brain
  • Humans
  • Cardiovascular System & Hematology
  • Body Mass Index
  • Biomarkers