Understanding amino-terminal pro-B-type natriuretic peptide in obesity.


Journal Article (Review)

Concentrations of both B-type natriuretic peptide (BNP) and its amino-terminal cleavage fragment (NT-proBNP) are relatively lower among patients with a higher body mass index (BMI). Based on data at hand, this is probably related to reduced synthesis or secretion of the peptides, rather than increased clearance (which may play only a minor role in this context). Despite this fact, age-adjusted NT-proBNP cut points to "rule in" heart failure (HF) and age-independent cut points to "rule out" HF in patients with acute dyspnea are equally useful for obese and lean patients, and no adjustment of NT-proBNP thresholds for BMI is recommended. Furthermore, the consensus-recommended NT-proBNP cut point of 1,000 ng/L for prognostication in acute dyspnea is equally useful across all BMI categories, without the need for further adjustment for weight. Thus, despite the BMI-related NP handicap observed in overweight and obese patients, NT-proBNP remains powerfully useful for diagnostic and prognostic evaluation across the entire range of BMI values.

Full Text

Duke Authors

Cited Authors

  • Bayes-Genis, A; DeFilippi, C; Januzzi, JL

Published Date

  • February 4, 2008

Published In

Volume / Issue

  • 101 / 3A

Start / End Page

  • 89 - 94

PubMed ID

  • 18243866

Pubmed Central ID

  • 18243866

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2007.11.030


  • eng

Conference Location

  • United States