Gender-related differences in acute aortic dissection.


Journal Article

BACKGROUND: Few data exist on gender-related differences in clinical presentation, diagnostic findings, management, and outcomes in acute aortic dissection (AAD). METHODS AND RESULTS: Accordingly, we evaluated 1078 patients enrolled in the International Registry of Acute Aortic Dissection (IRAD) to assess differences in clinical features, management, and in-hospital outcomes between men and women. Of the patients enrolled in IRAD (32.1%) with AAD, 346 were women. Although less frequently affected by AAD (32.1% of AAD), women were significantly older and had more often presented later than men (P=0.008); symptoms of coma/altered mental status were more common, whereas pulse deficit was less common. Diagnostic imaging suggestive of rupture, ie, periaortic hematoma, and pleural or pericardial effusion were more commonly observed in women. In-hospital complications of hypotension and tamponade occurred with greater frequency in women, resulting in higher in-hospital mortality compared with men. After adjustment for age and hypertension, women with aortic dissection die more frequently than men (OR, 1.4, P=0.04), predominantly in the 66- to 75-year age group. Moreover, surgical outcome was worse in women than men (P=0.013); type A dissection in women was associated with a higher surgical mortality of 32% versus 22% in men despite similar delay, surgical technique, and hemodynamics. CONCLUSIONS: Our analysis provides insights into gender-related differences in AAD with regard to clinical characteristics, management, and outcomes; important diagnostic and therapeutic implications may help shed light on aortic dissection in women to improve their outcomes.

Full Text

Duke Authors

Cited Authors

  • Nienaber, CA; Fattori, R; Mehta, RH; Richartz, BM; Evangelista, A; Petzsch, M; Cooper, JV; Januzzi, JL; Ince, H; Sechtem, U; Bossone, E; Fang, J; Smith, DE; Isselbacher, EM; Pape, LA; Eagle, KA; International Registry of Acute Aortic Dissection,

Published Date

  • June 22, 2004

Published In

Volume / Issue

  • 109 / 24

Start / End Page

  • 3014 - 3021

PubMed ID

  • 15197151

Pubmed Central ID

  • 15197151

Electronic International Standard Serial Number (EISSN)

  • 1524-4539

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000130644.78677.2C


  • eng

Conference Location

  • United States