Comparison of symptoms, treatment, and outcomes of coronary artery disease among rheumatoid arthritis and matched subjects undergoing percutaneous coronary intervention.


Journal Article

OBJECTIVE: Rheumatoid arthritis (RA) is associated with an increased prevalence of coronary artery disease (CAD). We investigated the presenting symptoms of CAD, coronary anatomy (single versus multi-vessel CAD), and treatment among a group of subjects undergoing percutaneous coronary intervention (PCI) with angioplasty and/or stenting. METHODS: We evaluated a retrospective cohort of 43 RA subjects and 43 matched non-RA subjects undergoing PCI at 2 academic referral centers. RA subjects were matched to non-RA subjects on age, gender, history of coronary artery bypass grafting, date of PCI, and interventional cardiologist. We compared cardiac risk factors, presentation, treatment, and outcomes. RESULTS: The mean age of the study cohort was 71 ± 10 years, and the distribution of traditional cardiac risk factors was similar in the subjects with RA compared with the matched non-RA subjects (all P values > 0.05). Seventy-four percent of subjects with RA compared with 67% of those without RA presented with an acute coronary syndrome before PCI (P = 0.48). All subjects in this cohort undergoing PCI had at least 1 stenosis in a major epicardial vessel and similar percentages of subjects with RA (44%) and without RA (40%) had multi-vessel CAD (P = 0.66). The administration of cardiac medications both at PCI and at hospital discharge was not different among subjects with RA compared with matched non-RA subjects. CONCLUSIONS: Among this cohort with significant CAD undergoing PCI, clinical characteristics, presentation, severity of CAD, treatment modalities, and outcomes were similar in subjects with RA and well-matched non-RA subjects.

Full Text

Duke Authors

Cited Authors

  • Desai, SP; Januzzi, JL; Pande, AN; Pomerantsev, EV; Resnic, FS; Fossel, A; Chibnik, LB; Solomon, DH

Published Date

  • December 2010

Published In

Volume / Issue

  • 40 / 3

Start / End Page

  • 215 - 221

PubMed ID

  • 20541791

Pubmed Central ID

  • 20541791

Electronic International Standard Serial Number (EISSN)

  • 1532-866X

Digital Object Identifier (DOI)

  • 10.1016/j.semarthrit.2010.04.002


  • eng

Conference Location

  • United States