Association between anxiety and C-reactive protein levels in stable coronary heart disease patients.


Journal Article

BACKGROUND: Anxiety is highly prevalent among patients with stable coronary heart disease (CHD). However, the biologic effects that may connect these two seemingly unrelated disorders is not well understood. OBJECTIVE: This study aimed for a comprehensive evaluation of anxiety in stable CHD patients, in addition to cardiac biomarkers such as C-reactive protein (CRP), troponin T, and amino-terminal pro-B-type brain natriuretic peptide. METHOD: The study included 43 CHD patients with anxiety disorder and 42 CHD patients without psychiatric disorder given the Structured Clinical Interview for DSM-IV. RESULTS: Regression analyses showed an association between anxiety (anxiety disorder, not otherwise specified) and CRP levels, despite model adjustment for various related demographic and clinical variables. Anxiety was associated with CRP levels. CONCLUSION: There are significant associations between anxiety and CHD risk, with a potential biologic link between anxiety and elevations in a biomarker with powerful prognostic risk, namely CRP. It is not clear whether this association is directly causal or relates to other medical processes among patients with heightened anxiety. The findings suggest that the current focus on depressive disorders with respect to biomarkers and CHD outcomes should be broadened to include anxiety disorders, as well.

Full Text

Duke Authors

Cited Authors

  • Bankier, B; Barajas, J; Martinez-Rumayor, A; Januzzi, JL

Published Date

  • July 2009

Published In

Volume / Issue

  • 50 / 4

Start / End Page

  • 347 - 353

PubMed ID

  • 19687175

Pubmed Central ID

  • 19687175

Electronic International Standard Serial Number (EISSN)

  • 1545-7206

Digital Object Identifier (DOI)

  • 10.1176/appi.psy.50.4.347


  • eng

Conference Location

  • England