New York Heart Association class versus amino-terminal pro-B type natriuretic peptide for acute heart failure prognosis.


Journal Article

BACKGROUND: The prognostic value of the New York Heart Association classification (NYHAC) in acutely decompensated heart failure (ADHF) is unknown. OBJECTIVES: We sought to determine the relative value of NYHAC among patients with concomitantly measured amino-terminal pro-B type natriuretic peptide (NT-proBNP) at presentation with ADHF. MATERIALS AND METHODS: NYHAC was determined for 720 patients with ADHF and 1-year mortality status was examined. Cox-proportional hazards analysis compared the prognostic accuracy of NYHAC with other ADHF risk measures. RESULTS: NYHAC had a significant univariate association with 1-year mortality status (HR 1.41, 95% confidence interval (CI) 1.03-1.94; p = 0.03) but was not a significant predictor of death in a multivariable model that included NT-proBNP (HR 2.14; 95% CI 1.65-2.81, p < 0.001). CONCLUSIONS: In contrast to objective measures such as NT-proBNP, the NYHAC appears to provide limited prognostic information among individuals with ADHF.

Full Text

Duke Authors

Cited Authors

  • Baggish, AL; van Kimmenade, RRJ; Pinto, Y; Richards, AM; Lainchbury, J; Bayes-Genis, A; Santaló, M; Ordonez-Llanos, J; Januzzi, JL

Published Date

  • June 2010

Published In

Volume / Issue

  • 15 / 4

Start / End Page

  • 307 - 314

PubMed ID

  • 20370326

Pubmed Central ID

  • 20370326

Electronic International Standard Serial Number (EISSN)

  • 1366-5804

Digital Object Identifier (DOI)

  • 10.3109/13547501003632580


  • eng

Conference Location

  • England