Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial.
BACKGROUND: Stress myocyte biomarkers are used prognostically in patients with cardiovascular disease. We examined associations between amino-terminal pro-B-type natriuretic peptide (NT-proBNP), midregional pro-A-type natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) concentrations and cardiac chamber volumes in chest pain patients without heart failure by use of computed tomography (CT). METHODS: At the time of 64-slice CT scan, we acquired plasma and serum samples for these biomarkers from 346 patients [mean (SD) age 53 (12) years, 65% men]. Left atrial volume (LAV) and left ventricular volumes at end-diastole (LVEDV) and end-systole (LVESV) were measured and indexed to body surface area (LAVI, LVEDI, LVESI). RESULTS: Concentrations of both natriuretic peptides were correlated with LAV and LAVI (r = 0.19-0.32, all P
Truong, QA; Siegel, E; Karakas, M; Januzzi, JL; Bamberg, F; Mahabadi, AA; Dasdemir, S; Brady, TJ; Bergmann, A; Kunde, J; Nagurney, JT; Hoffmann, U; Koenig, W
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