Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial.


Journal Article

BACKGROUND:Stress myocyte biomarkers are used prognostically in patients with cardiovascular disease. We examined associations between amino-terminal pro-B-type natriuretic peptide (NT-proBNP), midregional pro-A-type natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) concentrations and cardiac chamber volumes in chest pain patients without heart failure by use of computed tomography (CT). METHODS:At the time of 64-slice CT scan, we acquired plasma and serum samples for these biomarkers from 346 patients [mean (SD) age 53 (12) years, 65% men]. Left atrial volume (LAV) and left ventricular volumes at end-diastole (LVEDV) and end-systole (LVESV) were measured and indexed to body surface area (LAVI, LVEDI, LVESI). RESULTS:Concentrations of both natriuretic peptides were correlated with LAV and LAVI (r = 0.19-0.32, all P

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Cited Authors

  • Truong, QA; Siegel, E; Karakas, M; Januzzi, JL; Bamberg, F; Mahabadi, AA; Dasdemir, S; Brady, TJ; Bergmann, A; Kunde, J; Nagurney, JT; Hoffmann, U; Koenig, W

Published Date

  • April 2010

Published In

Volume / Issue

  • 56 / 4

Start / End Page

  • 651 - 660

PubMed ID

  • 20185624

Pubmed Central ID

  • 20185624

Electronic International Standard Serial Number (EISSN)

  • 1530-8561

International Standard Serial Number (ISSN)

  • 0009-9147

Digital Object Identifier (DOI)

  • 10.1373/clinchem.2009.138586


  • eng