Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction.


Journal Article

BACKGROUND: Depression (MDD) and anxiety have been associated with negative long-term outcomes among patients with acute myocardial infarction (MI). OBJECTIVE: The objective of the study was to determine whether MDD and anxiety preceding MI were associated with in-hospital post-MI cardiac complications. METHOD: Subjects (N=129) underwent psychiatric interviews within 72 hours of MI and were evaluated for five in-hospital cardiac complications (recurrent ischemia, ventricular arrhythmia, ventricular arrhythmia requiring intervention, congestive heart failure, and reinfarction). RESULTS: Current (pre-MI) MDD was a significant and independent predictor of all complications except recurrent ischemia on multivariate regression analysis. In contrast, pre-MI anxiety was not associated with complications. CONCLUSION: These findings underscore the importance of identifying and treating MDD in post-MI patients and those at risk for MI.

Full Text

Duke Authors

Cited Authors

  • Huffman, JC; Smith, FA; Blais, MA; Taylor, AM; Januzzi, JL; Fricchione, GL

Published Date

  • July 2008

Published In

Volume / Issue

  • 49 / 4

Start / End Page

  • 309 - 316

PubMed ID

  • 18621936

Pubmed Central ID

  • 18621936

International Standard Serial Number (ISSN)

  • 0033-3182

Digital Object Identifier (DOI)

  • 10.1176/appi.psy.49.4.309


  • eng

Conference Location

  • England