Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure.


Journal Article

BACKGROUND: To prospectively determine the prognostic utility of serial sampling of the interleukin-1 receptor family member, ST2, for predicting 90-day mortality in patients with heart failure (HF) admitted to a Veteran Affairs Medical Center. METHODS AND RESULTS: A total 150 patients hospitalized with acutely destabilized HF were followed at the Veteran Affairs Healthcare System in San Diego, CA. Multiple cardiac-related parameters were measured including ST2, B-type natriuretic peptide (BNP), NT-proBNP, and blood urea nitrogen (BUN). Plasma samples were collected at 6 time points between admission and discharge. Biomarker concentrations were correlated to survival at 90 days. Uni- and multivariate analyses were used to identify prognostic variables. From admission to discharge, percent change in ST2 was strongly predictive of 90-day mortality: those patients whose ST2 values decreased by 15.5% or more during the study period had a 7% chance of death, whereas patients whose ST2 levels failed to decrease by 15.5% in this time interval had a 33% chance of dying. CONCLUSIONS: Percent change in ST2 concentrations during acute HF treatment is predictive of 90-day mortality and was independent of BNP or NT-proBNP levels. ST2 may provide clinicians with an additional tool for guiding treatment in patients with acute destabilized HF.

Full Text

Duke Authors

Cited Authors

  • Boisot, S; Beede, J; Isakson, S; Chiu, A; Clopton, P; Januzzi, J; Maisel, AS; Fitzgerald, RL

Published Date

  • November 2008

Published In

Volume / Issue

  • 14 / 9

Start / End Page

  • 732 - 738

PubMed ID

  • 18995177

Pubmed Central ID

  • 18995177

Electronic International Standard Serial Number (EISSN)

  • 1532-8414

Digital Object Identifier (DOI)

  • 10.1016/j.cardfail.2008.06.415


  • eng

Conference Location

  • United States