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Recovery from heart failure: structural and functional analysis in a canine model.

Publication ,  Journal Article
Howard, RJ; Stopps, TP; Moe, GW; Gotlieb, A; Armstrong, PW
Published in: Can J Physiol Pharmacol
December 1988

Chronic, rapid ventricular pacing produces congestive heart failure in the dog. Using echocardiography, the features of developing heart failure were analysed and the capacity of this model for recovery was assessed once pacing had been discontinued. Fifteen dogs were studied; nine were paced at 250 beats/min (bpm) to severe heart failure (5.0 +/- 1.8 weeks) and six served as sham controls. In the paced animals at severe heart failure, two-dimensional echocardiography demonstrated a significant increase in diastolic cross-sectional cardiac area (from 11 +/- 3 to 16 +/- 2 cm2, p less than 0.05), associated with a marked fall n area ejection fraction (54 +/- 8 to 21 +/- 8%, p less than 0.05), and significant left ventricular wall thinning (from 6.0 +/- 0.7 to 4.7 +/- 0.9 mm, p less than 0.05). In addition, significant increases in heart rate (77 +/- 7 to 126 +/- 13 bpm, sinus rhythm; p less than 0.05), respiratory rate (41 +/- 13 to 80 +/- 20 cycles/min, p less than 0.05), and body weight (21 +/- 1 to 24 +/- 3 kg, p less than 0.05) were noted. Serum sodium fell (146 +/- 3 to 140 +/- 8 mmol/L, p less than 0.05), while blood urea nitrogen (6 +/- 2 to 10 +/- 2 mmol/L, p less than 0.05) and creatinine (86 +/- 12 to 101 +/- 15 mmol/d, p less than 0.05) increased. Recovery was characterized by rapid improvement such that all measured parameters normalized by 1 week, except for cross-sectional cardiac area which remained dilated up to 4 weeks (14 +/- 3 cm2, p less than 0.05 versus control).(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

December 1988

Volume

66

Issue

12

Start / End Page

1505 / 1512

Location

Canada

Related Subject Headings

  • Remission, Spontaneous
  • Physiology
  • Male
  • Hemodynamics
  • Heart Failure
  • Echocardiography
  • Dogs
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3208 Medical physiology
 

Citation

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Howard, R. J., Stopps, T. P., Moe, G. W., Gotlieb, A., & Armstrong, P. W. (1988). Recovery from heart failure: structural and functional analysis in a canine model. Can J Physiol Pharmacol, 66(12), 1505–1512. https://doi.org/10.1139/y88-246
Howard, R. J., T. P. Stopps, G. W. Moe, A. Gotlieb, and P. W. Armstrong. “Recovery from heart failure: structural and functional analysis in a canine model.Can J Physiol Pharmacol 66, no. 12 (December 1988): 1505–12. https://doi.org/10.1139/y88-246.
Howard RJ, Stopps TP, Moe GW, Gotlieb A, Armstrong PW. Recovery from heart failure: structural and functional analysis in a canine model. Can J Physiol Pharmacol. 1988 Dec;66(12):1505–12.
Howard, R. J., et al. “Recovery from heart failure: structural and functional analysis in a canine model.Can J Physiol Pharmacol, vol. 66, no. 12, Dec. 1988, pp. 1505–12. Pubmed, doi:10.1139/y88-246.
Howard RJ, Stopps TP, Moe GW, Gotlieb A, Armstrong PW. Recovery from heart failure: structural and functional analysis in a canine model. Can J Physiol Pharmacol. 1988 Dec;66(12):1505–1512.

Published In

Can J Physiol Pharmacol

DOI

ISSN

0008-4212

Publication Date

December 1988

Volume

66

Issue

12

Start / End Page

1505 / 1512

Location

Canada

Related Subject Headings

  • Remission, Spontaneous
  • Physiology
  • Male
  • Hemodynamics
  • Heart Failure
  • Echocardiography
  • Dogs
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3208 Medical physiology