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Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure.

Publication ,  Journal Article
Moe, GW; Grima, EA; Howard, RJ; Armstrong, PW
Published in: J Card Fail
June 1996

BACKGROUND: The canine model of pacing-induced heart failure is characterized by an absence of ventricular hypertrophy despite severe hemodynamic stress and neurohormonal activation. Given the mode of ventricular pacing, hypertrophy might occur in the atrial appendage. METHODS AND RESULTS: Seventeen dogs underwent continuous right ventricular pacing for 3 weeks to severe heart failure. Twelve normal dogs served as control subjects. Pacing produced marked increases in both pulmonary capillary wedge pressure (7.6 +/- 1.8 mmHg at baseline to 32.6 +/- 7.5 mmHg at 3 weeks, P < .001) and right atrial pressure (6.5 +/- 1.8 to 15.1 +/- 2.4 mmHg, P < .001), marked increases in normalized left ventricular volume (3.0 +/- 0.5 to 4.6 +/- 0.5 mL/kg, P < .001) and left atrial volume (1.0 +/- 0.2 to 2.6 +/- 0.5 mL/kg, P < .001), but no change in left ventricular mass (2.3 +/- 0.4 to 2.6 +/- 0.5 g/kg, differences not significant), indicating no ventricular hypertrophy. Compared to the control dogs, total heart weight in the test animals was similar, but both the left appendage (0.18 +/- 0.04 vs 0.10 +/- 0.03 g/kg, P < .001) and right atrial appendage (0.15 +/- 0.03 vs 0.12 +/- 0.02 g/kg, P = .004) were much heavier than those of the control dogs. CONCLUSIONS: Rapid right ventricular pacing in the dog induces severe heart failure associated with a dichotomous response in the atrial appendage versus the ventricle. Aside from being a useful heart failure model that simulates the human condition, this unique feature may have physiologic implications in terms of atrial mechanical and endocrine functions and have applications for future studies into the mechanisms of cardiac remodeling and hypertrophy.

Duke Scholars

Published In

J Card Fail

DOI

ISSN

1071-9164

Publication Date

June 1996

Volume

2

Issue

2

Start / End Page

127 / 132

Location

United States

Related Subject Headings

  • Organ Size
  • Male
  • Hypertrophy, Left Ventricular
  • Hypertrophy
  • Hemodynamics
  • Heart Failure
  • Heart Atria
  • Echocardiography
  • Dogs
  • Cardiovascular System & Hematology
 

Citation

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Moe, G. W., Grima, E. A., Howard, R. J., & Armstrong, P. W. (1996). Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure. J Card Fail, 2(2), 127–132. https://doi.org/10.1016/s1071-9164(96)80031-5
Moe, G. W., E. A. Grima, R. J. Howard, and P. W. Armstrong. “Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure.J Card Fail 2, no. 2 (June 1996): 127–32. https://doi.org/10.1016/s1071-9164(96)80031-5.
Moe GW, Grima EA, Howard RJ, Armstrong PW. Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure. J Card Fail. 1996 Jun;2(2):127–32.
Moe, G. W., et al. “Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure.J Card Fail, vol. 2, no. 2, June 1996, pp. 127–32. Pubmed, doi:10.1016/s1071-9164(96)80031-5.
Moe GW, Grima EA, Howard RJ, Armstrong PW. Biatrial appendage hypertrophy but not ventricular hypertrophy: a unique feature of canine pacing-induced heart failure. J Card Fail. 1996 Jun;2(2):127–132.
Journal cover image

Published In

J Card Fail

DOI

ISSN

1071-9164

Publication Date

June 1996

Volume

2

Issue

2

Start / End Page

127 / 132

Location

United States

Related Subject Headings

  • Organ Size
  • Male
  • Hypertrophy, Left Ventricular
  • Hypertrophy
  • Hemodynamics
  • Heart Failure
  • Heart Atria
  • Echocardiography
  • Dogs
  • Cardiovascular System & Hematology