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Beta adrenoceptor recovery after heart failure in the dog.

Publication ,  Journal Article
Larosa, G; Armstrong, PW; Seeman, P; Forster, C
Published in: Cardiovasc Res
March 1993

OBJECTIVE: The role of myocardial beta receptors in pacing induced congestive heart failure is uncertain. The aims of the study were therefore (1) to examine total beta adrenoceptor density in canine left ventricle during pacing induced heart failure; and (2) to evaluate whether there is a relationship between beta adrenoceptor numbers and circulating noradrenaline during progression of heart failure. METHODS: Heart failure was examined at different stages: early (after 1 week of pacing at 250 beats.min-1); peak (after 4 weeks of pacing); and after recovery (4 weeks after pacing was discontinued). Myocardial beta adrenoceptor density was assessed by radioligand binding with iodocyanopindolol. Plasma noradrenaline was determined by high performance liquid chromatography with electrochemical detection. RESULTS: Compared to control, left ventricular beta adrenoceptor density was: (1) not significantly different in early heart failure, at 2540(SEM 460) v 3160(260) fmol.g-1 wet weight in control; (2) decreased 63% at peak heart failure [1180(100) fmol.g-1, p < 0.01]; and (3) restored to control density after recovery from heart failure [3430(540) fmol.g-1]. The beta adrenoceptor dissociation constant was unaltered throughout. There was an inverse correlation between myocardial beta adrenoceptor density and plasma noradrenaline (r = -0.785, p < 0.01). CONCLUSIONS: The progressive decline in beta adrenoceptor density as heart failure develops and the capacity of beta adrenoceptors to return to control levels after recovery from the experimental heart failure state suggests that there is a reversible abnormality in beta adrenoceptors during heart failure.

Duke Scholars

Published In

Cardiovasc Res

DOI

ISSN

0008-6363

Publication Date

March 1993

Volume

27

Issue

3

Start / End Page

489 / 493

Location

England

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Norepinephrine
  • Myocardium
  • Male
  • Heart Rate
  • Heart Failure
  • Dogs
  • Disease Models, Animal
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial
 

Citation

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Larosa, G., Armstrong, P. W., Seeman, P., & Forster, C. (1993). Beta adrenoceptor recovery after heart failure in the dog. Cardiovasc Res, 27(3), 489–493. https://doi.org/10.1093/cvr/27.3.489
Larosa, G., P. W. Armstrong, P. Seeman, and C. Forster. “Beta adrenoceptor recovery after heart failure in the dog.Cardiovasc Res 27, no. 3 (March 1993): 489–93. https://doi.org/10.1093/cvr/27.3.489.
Larosa G, Armstrong PW, Seeman P, Forster C. Beta adrenoceptor recovery after heart failure in the dog. Cardiovasc Res. 1993 Mar;27(3):489–93.
Larosa, G., et al. “Beta adrenoceptor recovery after heart failure in the dog.Cardiovasc Res, vol. 27, no. 3, Mar. 1993, pp. 489–93. Pubmed, doi:10.1093/cvr/27.3.489.
Larosa G, Armstrong PW, Seeman P, Forster C. Beta adrenoceptor recovery after heart failure in the dog. Cardiovasc Res. 1993 Mar;27(3):489–493.
Journal cover image

Published In

Cardiovasc Res

DOI

ISSN

0008-6363

Publication Date

March 1993

Volume

27

Issue

3

Start / End Page

489 / 493

Location

England

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Norepinephrine
  • Myocardium
  • Male
  • Heart Rate
  • Heart Failure
  • Dogs
  • Disease Models, Animal
  • Cardiovascular System & Hematology
  • Cardiac Pacing, Artificial