Acute reduction of lipoprotein(a) by tissue-type plasminogen activator.


Journal Article

BACKGROUND: Lipoprotein(a) [Lp(a)] is a low density lipoprotein-like particle whose apolipoprotein B (apo B) moiety is disulfide-linked to apo(a), a plasminogen-like inhibitor of fibrinolysis in vitro. We hypothesized that plasma concentrations of Lp(a) are acutely affected by intravenous tissue-type plasminogen activator (t-PA). METHODS AND RESULTS: Patients with unstable angina were randomized to receive either intravenous t-PA (n = 15) or placebo (n = 11). Two-way ANOVA using repeated measures revealed a significant effect of t-PA on concentrations of Lp(a) (p = 0.026). There was a 48% fall in Lp(a) from baseline concentrations in the t-PA group at 12 hours (p = 0.031) but not at 72 hours. Lp(a) in the placebo group was unchanged. CONCLUSIONS: We conclude that t-PA produces a sharp and substantial but reversible reduction in plasma Lp(a). These data suggest that Lp(a) concentration is not as static in vivo as had been believed and might be acutely modifiable through some mechanism that induces its removal from the freely circulating state.

Full Text

Duke Authors

Cited Authors

  • Hegele, RA; Freeman, MR; Langer, A; Connelly, PW; Armstrong, PW

Published Date

  • June 1992

Published In

Volume / Issue

  • 85 / 6

Start / End Page

  • 2034 - 2038

PubMed ID

  • 1534287

Pubmed Central ID

  • 1534287

International Standard Serial Number (ISSN)

  • 0009-7322

Digital Object Identifier (DOI)

  • 10.1161/01.cir.85.6.2034


  • eng

Conference Location

  • United States