Rapid stereoselective access to key pumiliotoxin precursors from a common intermediate.
Journal Article
Epoxidation and dihydroxylation of 8-methyl-2,3,6,8a-tetrahydro-1H-indolizin-5-one proceeded from the concave face with good selectivity and gave advanced precursors for pumiliotoxin and allopumiliotoxin synthesis, respectively. The origin of the selectivity is believed to be stereoelectronic in nature and allows rapid entry to three different pumiliotoxin classes from a common intermediate.
Full Text
Duke Authors
Cited Authors
- O'Mahony, G; Nieuwenhuyzen, M; Armstrong, P; Stevenson, PJ
Published Date
- May 2004
Published In
Volume / Issue
- 69 / 11
Start / End Page
- 3968 - 3971
PubMed ID
- 15153035
Electronic International Standard Serial Number (EISSN)
- 1520-6904
International Standard Serial Number (ISSN)
- 0022-3263
Digital Object Identifier (DOI)
- 10.1021/jo0497205
Language
- eng