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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Publication ,  Journal Article
Wen, W; Kato, N; Hwang, J-Y; Guo, X; Tabara, Y; Li, H; Dorajoo, R; Yang, X; Tsai, F-J; Li, S; Wu, Y; Wu, T; Kim, S; Guo, X; Liang, J ...
Published in: Sci Rep
January 20, 2016

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 20, 2016

Volume

6

Start / End Page

17958

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Waist Circumference
  • Sex Factors
  • Quantitative Trait, Heritable
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Obesity
  • Male
  • Humans
  • Genome-Wide Association Study
 

Citation

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Wen, W., Kato, N., Hwang, J.-Y., Guo, X., Tabara, Y., Li, H., … Shu, X.-O. (2016). Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep, 6, 17958. https://doi.org/10.1038/srep17958
Wen, Wanqing, Norihiro Kato, Joo-Yeon Hwang, Xingyi Guo, Yasuharu Tabara, Huaixing Li, Rajkumar Dorajoo, et al. “Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.Sci Rep 6 (January 20, 2016): 17958. https://doi.org/10.1038/srep17958.
Wen W, Kato N, Hwang J-Y, Guo X, Tabara Y, Li H, et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20;6:17958.
Wen, Wanqing, et al. “Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.Sci Rep, vol. 6, Jan. 2016, p. 17958. Pubmed, doi:10.1038/srep17958.
Wen W, Kato N, Hwang J-Y, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai F-J, Li S, Wu Y, Wu T, Kim S, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang L-C, Chen C-H, Chen Y-T, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han B-G, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Kang D, Kim YJ, Kita Y, Lee J, Lee NR, Wang Y, Liu J-J, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang Y-B, Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL, He J, Mo Z, Wu J-Y, Tai ES, Lin X, Miki T, Kim B-J, Takeuchi F, Zheng W, Shu X-O. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20;6:17958.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 20, 2016

Volume

6

Start / End Page

17958

Location

England

Related Subject Headings

  • Waist-Hip Ratio
  • Waist Circumference
  • Sex Factors
  • Quantitative Trait, Heritable
  • Quantitative Trait Loci
  • Polymorphism, Single Nucleotide
  • Obesity
  • Male
  • Humans
  • Genome-Wide Association Study