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Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.

Publication ,  Journal Article
Jiang, C; Luo, P; Zhao, Y; Hong, J; Morris-Natschke, SL; Xu, J; Chen, C-H; Lee, K-H; Gu, Q
Published in: J Nat Prod
March 25, 2016

Seven new carolignans, including two pairs of enantiomers (±)-erythro-7'-methylcarolignan E (1a/1b) and (±)-threo-7'-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (-)-erythro-carolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8-13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC50 values of 6.3 and 5.3 μM.

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Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

March 25, 2016

Volume

79

Issue

3

Start / End Page

578 / 583

Location

United States

Related Subject Headings

  • Stereoisomerism
  • Plant Components, Aerial
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Lignans
  • Euphorbia
  • Drugs, Chinese Herbal
  • Circular Dichroism
  • Anti-HIV Agents
 

Citation

APA
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ICMJE
MLA
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Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., … Gu, Q. (2016). Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod, 79(3), 578–583. https://doi.org/10.1021/acs.jnatprod.5b01012
Jiang, Cheng, Pan Luo, Yu Zhao, Jialing Hong, Susan L. Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee, and Qiong Gu. “Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.J Nat Prod 79, no. 3 (March 25, 2016): 578–83. https://doi.org/10.1021/acs.jnatprod.5b01012.
Jiang C, Luo P, Zhao Y, Hong J, Morris-Natschke SL, Xu J, et al. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod. 2016 Mar 25;79(3):578–83.
Jiang, Cheng, et al. “Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.J Nat Prod, vol. 79, no. 3, Mar. 2016, pp. 578–83. Pubmed, doi:10.1021/acs.jnatprod.5b01012.
Jiang C, Luo P, Zhao Y, Hong J, Morris-Natschke SL, Xu J, Chen C-H, Lee K-H, Gu Q. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod. 2016 Mar 25;79(3):578–583.
Journal cover image

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

March 25, 2016

Volume

79

Issue

3

Start / End Page

578 / 583

Location

United States

Related Subject Headings

  • Stereoisomerism
  • Plant Components, Aerial
  • Nuclear Magnetic Resonance, Biomolecular
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Lignans
  • Euphorbia
  • Drugs, Chinese Herbal
  • Circular Dichroism
  • Anti-HIV Agents