Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.

Published

Journal Article

Seven new carolignans, including two pairs of enantiomers (±)-erythro-7'-methylcarolignan E (1a/1b) and (±)-threo-7'-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (-)-erythro-carolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8-13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC50 values of 6.3 and 5.3 μM.

Full Text

Duke Authors

Cited Authors

  • Jiang, C; Luo, P; Zhao, Y; Hong, J; Morris-Natschke, SL; Xu, J; Chen, C-H; Lee, K-H; Gu, Q

Published Date

  • March 25, 2016

Published In

Volume / Issue

  • 79 / 3

Start / End Page

  • 578 - 583

PubMed ID

  • 26756779

Pubmed Central ID

  • 26756779

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.5b01012

Language

  • eng

Conference Location

  • United States