Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.
Publication
, Journal Article
Jiang, C; Luo, P; Zhao, Y; Hong, J; Morris-Natschke, SL; Xu, J; Chen, C-H; Lee, K-H; Gu, Q
Published in: J Nat Prod
March 25, 2016
Seven new carolignans, including two pairs of enantiomers (±)-erythro-7'-methylcarolignan E (1a/1b) and (±)-threo-7'-methylcarolignan E (2a/2b), (+)-threo-carolignan E (3a), (+)-erythro-carolignan E (4a), and (-)-erythro-carolignan Z (5), together with four known lignans (3b, 4b, 6, and 7) and six polyphenols (8-13) were isolated from the aerial parts of Euphorbia sikkimensis. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined by electronic circular dichroism calculations. Seven of the isolates were examined for anti-HIV effects, and compounds 1a and 1b showed moderate anti-HIV activity with EC50 values of 6.3 and 5.3 μM.
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Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
March 25, 2016
Volume
79
Issue
3
Start / End Page
578 / 583
Location
United States
Related Subject Headings
- Stereoisomerism
- Plant Components, Aerial
- Nuclear Magnetic Resonance, Biomolecular
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Lignans
- Euphorbia
- Drugs, Chinese Herbal
- Circular Dichroism
- Anti-HIV Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., … Gu, Q. (2016). Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod, 79(3), 578–583. https://doi.org/10.1021/acs.jnatprod.5b01012
Jiang, Cheng, Pan Luo, Yu Zhao, Jialing Hong, Susan L. Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee, and Qiong Gu. “Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.” J Nat Prod 79, no. 3 (March 25, 2016): 578–83. https://doi.org/10.1021/acs.jnatprod.5b01012.
Jiang C, Luo P, Zhao Y, Hong J, Morris-Natschke SL, Xu J, et al. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod. 2016 Mar 25;79(3):578–83.
Jiang, Cheng, et al. “Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity.” J Nat Prod, vol. 79, no. 3, Mar. 2016, pp. 578–83. Pubmed, doi:10.1021/acs.jnatprod.5b01012.
Jiang C, Luo P, Zhao Y, Hong J, Morris-Natschke SL, Xu J, Chen C-H, Lee K-H, Gu Q. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. J Nat Prod. 2016 Mar 25;79(3):578–583.
Published In
J Nat Prod
DOI
EISSN
1520-6025
Publication Date
March 25, 2016
Volume
79
Issue
3
Start / End Page
578 / 583
Location
United States
Related Subject Headings
- Stereoisomerism
- Plant Components, Aerial
- Nuclear Magnetic Resonance, Biomolecular
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Lignans
- Euphorbia
- Drugs, Chinese Herbal
- Circular Dichroism
- Anti-HIV Agents