Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.

Published

Journal Article

The design of drug delivery systems capable of efficiently delivering poorly soluble drugs to target sites still remains a major challenge. Such materials require several different functionalities; typically, these materials should be biodegradable and nontoxic, nonimmunogenic, responsive to their environment, and soluble in aqueous solution while retaining the ability to solubilize hydrophobic drugs. Here, a polypeptide-polymer hybrid of elastin-like polypeptides (ELPs) and poly(2-oxazoline)s (POx) is reported. This paper describes the chemical synthesis, physical characteristics, and drug loading potential of these novel hybrid macromolecules. A novel method is introduced for terminal functionalization of POx with protected maleimide moieties. Following recovery of the maleimide group via a retro Diels-Alder reaction, the consecutive Michael addition of thiol-functionalized ELPs yields the desired protein-polymer conjugate. These conjugates form nanoparticles in aqueous solution capable of solubilizing the anti-cancer drug paclitaxel with up to 8 wt% loading.

Full Text

Duke Authors

Cited Authors

  • Nawroth, JF; McDaniel, JR; Chilkoti, A; Jordan, R; Luxenhofer, R

Published Date

  • March 2016

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 322 - 333

PubMed ID

  • 26756582

Pubmed Central ID

  • 26756582

Electronic International Standard Serial Number (EISSN)

  • 1616-5195

International Standard Serial Number (ISSN)

  • 1616-5187

Digital Object Identifier (DOI)

  • 10.1002/mabi.201500376

Language

  • eng