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Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates.

Publication ,  Journal Article
Cole, MA; DeRienzo, C; Kutchibhatla, M; Cotten, CM; Adibe, OO
Published in: Am J Surg
April 2016

BACKGROUND: Necrotizing enterocolitis (NEC) is a gastrointestinal disease of premature, very low birth weight neonates resulting in sepsis and death. Loop diuretics are widely used in neonates as a treatment for pulmonary fluid retention. An association between diuretic use and NEC has not been explored. METHODS: The medical records of all neonates admitted to Duke Children's Hospital between 2007 and 2012 with a birth weight ≤1,500 grams were reviewed. RESULTS: Using multivariable logistic regression analysis, we found that loop diuretic administration was not a risk factor for the development of NEC. On subanalysis, 75% of medical NEC infants had prior exposure to loop diuretics, compared with 100% of surgical NEC infants (P = .004). CONCLUSIONS: Loop diuretics do not increase the risk of development of NEC in very low birth weight neonates. However, on diagnosis of NEC, administration of loop diuretics may be associated with the progression of NEC severity from medical NEC to surgical NEC.

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Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

April 2016

Volume

211

Issue

4

Start / End Page

645 / 648

Location

United States

Related Subject Headings

  • Surgery
  • Sodium Potassium Chloride Symporter Inhibitors
  • Severity of Illness Index
  • North Carolina
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Humans
 

Citation

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Cole, M. A., DeRienzo, C., Kutchibhatla, M., Cotten, C. M., & Adibe, O. O. (2016). Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates. Am J Surg, 211(4), 645–648. https://doi.org/10.1016/j.amjsurg.2015.11.015
Cole, Mariatu A., Christopher DeRienzo, Maragatha Kutchibhatla, Charles Michael Cotten, and Obinna O. Adibe. “Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates.Am J Surg 211, no. 4 (April 2016): 645–48. https://doi.org/10.1016/j.amjsurg.2015.11.015.
Cole MA, DeRienzo C, Kutchibhatla M, Cotten CM, Adibe OO. Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates. Am J Surg. 2016 Apr;211(4):645–8.
Cole, Mariatu A., et al. “Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates.Am J Surg, vol. 211, no. 4, Apr. 2016, pp. 645–48. Pubmed, doi:10.1016/j.amjsurg.2015.11.015.
Cole MA, DeRienzo C, Kutchibhatla M, Cotten CM, Adibe OO. Necrotizing enterocolitis and the use of loop diuretics in very low birth weight neonates. Am J Surg. 2016 Apr;211(4):645–648.
Journal cover image

Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

April 2016

Volume

211

Issue

4

Start / End Page

645 / 648

Location

United States

Related Subject Headings

  • Surgery
  • Sodium Potassium Chloride Symporter Inhibitors
  • Severity of Illness Index
  • North Carolina
  • Male
  • Intensive Care Units, Neonatal
  • Infant, Very Low Birth Weight
  • Infant, Premature
  • Infant, Newborn
  • Humans