Current State of Stem Cell Therapy for Ischemic Heart Disease.


Journal Article (Review)

Improvements in the care of patients with ischemic cardiovascular disease have led to improved survival but also a burgeoning population of patients with advanced ischemic heart disease. Cell therapies offer a novel approach toward cardiac "rejuvenation" via stimulation of new blood vessel growth, enhancing tissue perfusion, and via preservation or even regeneration of myocardial tissue, leading to improvements in cardiac performance after myocardial infarction and in patients with advanced heart failure. Here, we summarize and offer some thoughts on the state of the field of cell therapy for ischemic heart disease, targeting three separate conditions that have been the subject of significant clinical research: enhancing left ventricular recovery after MI, improving outcomes and symptoms in patients with congestive heart failure (CHF), and treatment of patients with refractory angina, despite maximal medical therapy.

Full Text

Duke Authors

Cited Authors

  • Povsic, TJ

Published Date

  • February 2016

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 17 -

PubMed ID

  • 26768743

Pubmed Central ID

  • 26768743

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-015-0693-6


  • eng

Conference Location

  • United States