Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer.
Journal Article (Journal Article)
A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire ‒ including antigen specificity, clonality, as well as its prognostic significance ‒ remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study the landscape and compartmentalization of these patients' TCR β repertoire by deep sequencing analyses. Our results illustrated antigen-driven expansion within the tumor compartment and the contracted size of shared clonotypes in mucosa and peripheral blood. Most importantly, the diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse.
Full Text
- Published version (via Digital Object Identifier)
- Pubmed Central version
- Open Access Copy from Duke
- Link to Item
Duke Authors
Cited Authors
- Jia, Q; Zhou, J; Chen, G; Shi, Y; Yu, H; Guan, P; Lin, R; Jiang, N; Yu, P; Li, Q-J; Wan, Y
Published Date
- April 2015
Published In
Volume / Issue
- 4 / 4
Start / End Page
- e1001230 -
PubMed ID
- 26137399
Pubmed Central ID
- PMC4485732
International Standard Serial Number (ISSN)
- 2162-4011
Digital Object Identifier (DOI)
- 10.1080/2162402X.2014.1001230
Language
- eng
Conference Location
- United States