Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer.

Published online

Journal Article

A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire ‒ including antigen specificity, clonality, as well as its prognostic significance ‒ remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study the landscape and compartmentalization of these patients' TCR β repertoire by deep sequencing analyses. Our results illustrated antigen-driven expansion within the tumor compartment and the contracted size of shared clonotypes in mucosa and peripheral blood. Most importantly, the diversity of mucosal T lymphocytes could independently predict prognosis, which strongly underscores critical roles of resident mucosal T-cells in executing post-surgery immunosurveillance against tumor relapse.

Full Text

Duke Authors

Cited Authors

  • Jia, Q; Zhou, J; Chen, G; Shi, Y; Yu, H; Guan, P; Lin, R; Jiang, N; Yu, P; Li, Q-J; Wan, Y

Published Date

  • April 2015

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • e1001230 -

PubMed ID

  • 26137399

Pubmed Central ID

  • 26137399

International Standard Serial Number (ISSN)

  • 2162-4011

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2014.1001230

Language

  • eng

Conference Location

  • United States