Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.

Journal Article (Journal Article)

We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.

Full Text

Duke Authors

Cited Authors

  • Armstrong, MJ; Stang, MT; Liu, Y; Gao, J; Ren, B; Zuckerbraun, BS; Mahidhara, RS; Xing, Q; Pizzoferrato, E; Yim, JH

Published Date

  • June 1, 2012

Published In

Volume / Issue

  • 319 / 1

Start / End Page

  • 56 - 65

PubMed ID

  • 22200613

Pubmed Central ID

  • PMC3304016

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2011.12.027

Language

  • eng

Conference Location

  • Ireland