Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.
Published
Journal Article
We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of the Inhibitor of Apoptosis Protein (IAP) survivin and the induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). In this report, we investigated the direct role of p21 in the suppression of survivin. We show that IRF-1 down-regulates cyclin B1, cdc-2, cyclin E, E2F1, Cdk2, Cdk4, and results in p21-mediated G1 cell cycle arrest. Interestingly, while p21 directly mediates G1 cell cycle arrest, IRF-1 or other IRF-1 signaling pathways may directly regulate survivin in human cancer cells.
Full Text
Duke Authors
Cited Authors
- Armstrong, MJ; Stang, MT; Liu, Y; Gao, J; Ren, B; Zuckerbraun, BS; Mahidhara, RS; Xing, Q; Pizzoferrato, E; Yim, JH
Published Date
- June 1, 2012
Published In
Volume / Issue
- 319 / 1
Start / End Page
- 56 - 65
PubMed ID
- 22200613
Pubmed Central ID
- 22200613
Electronic International Standard Serial Number (EISSN)
- 1872-7980
Digital Object Identifier (DOI)
- 10.1016/j.canlet.2011.12.027
Language
- eng
Conference Location
- Ireland