Skip to main content
Journal cover image

Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation.

Publication ,  Journal Article
Patel, YA; Berg, CL; Moylan, CA
Published in: Dig Dis Sci
May 2016

Nonalcoholic fatty liver disease (NAFLD) is the most common etiology of chronic liver disease in developed countries and is on trajectory to become the leading indication for liver transplantation in the USA and much of the world. Patients with NAFLD cirrhosis awaiting liver transplant face unique challenges and increased risk for waiting list stagnation and dropout due to burdensome comorbidities including obesity, diabetes, cardiovascular disease, and kidney disease. Thus far, patients transplanted for NAFLD cirrhosis have excellent mid- and long-term patient and graft survival, but concerns regarding short-term morbidity and mortality continue to exist. Post-liver transplantation, NAFLD occurs as both a recurrent and de novo manifestation, each with unique outcomes. NAFLD in the donor population is of concern given the growing demand for liver transplantation and mounting pressure to expand the donor pool. This review addresses key issues surrounding NAFLD as an indication for transplantation, including its increasing prevalence, unique patient demographics, outcomes related to liver transplantation, development of post-liver transplantation NAFLD, and NAFLD in the liver donor population. It also highlights exciting areas where further research is needed, such as the role of bariatric surgery and preconditioning of marginal donor grafts.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

May 2016

Volume

61

Issue

5

Start / End Page

1406 / 1416

Location

United States

Related Subject Headings

  • Risk Factors
  • Non-alcoholic Fatty Liver Disease
  • Liver Transplantation
  • Liver Cirrhosis
  • Humans
  • Gastroenterology & Hepatology
  • End Stage Liver Disease
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, Y. A., Berg, C. L., & Moylan, C. A. (2016). Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation. Dig Dis Sci, 61(5), 1406–1416. https://doi.org/10.1007/s10620-016-4035-3
Patel, Yuval A., Carl L. Berg, and Cynthia A. Moylan. “Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation.Dig Dis Sci 61, no. 5 (May 2016): 1406–16. https://doi.org/10.1007/s10620-016-4035-3.
Patel YA, Berg CL, Moylan CA. Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation. Dig Dis Sci. 2016 May;61(5):1406–16.
Patel, Yuval A., et al. “Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation.Dig Dis Sci, vol. 61, no. 5, May 2016, pp. 1406–16. Pubmed, doi:10.1007/s10620-016-4035-3.
Patel YA, Berg CL, Moylan CA. Nonalcoholic Fatty Liver Disease: Key Considerations Before and After Liver Transplantation. Dig Dis Sci. 2016 May;61(5):1406–1416.
Journal cover image

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

May 2016

Volume

61

Issue

5

Start / End Page

1406 / 1416

Location

United States

Related Subject Headings

  • Risk Factors
  • Non-alcoholic Fatty Liver Disease
  • Liver Transplantation
  • Liver Cirrhosis
  • Humans
  • Gastroenterology & Hepatology
  • End Stage Liver Disease
  • 3202 Clinical sciences
  • 1103 Clinical Sciences