Skip to main content

A targeted genetic association study of epithelial ovarian cancer susceptibility.

Publication ,  Journal Article
Earp, M; Winham, SJ; Larson, N; Permuth, JB; Sicotte, H; Chien, J; Anton-Culver, H; Bandera, EV; Berchuck, A; Cook, LS; Cramer, D; Doherty, JA ...
Published in: Oncotarget
February 16, 2016

BACKGROUND: Genome-wide association studies have identified several common susceptibility alleles for epithelial ovarian cancer (EOC). To further understand EOC susceptibility, we examined previously ungenotyped candidate variants, including uncommon variants and those residing within known susceptibility loci. RESULTS: At nine of eleven previously published EOC susceptibility regions (2q31, 3q25, 5p15, 8q21, 8q24, 10p12, 17q12, 17q21.31, and 19p13), novel variants were identified that were more strongly associated with risk than previously reported variants. Beyond known susceptibility regions, no variants were found to be associated with EOC risk at genome-wide statistical significance (p <5x10(-8)), nor were any significant after Bonferroni correction for 17,000 variants (p< 3x10-6). METHODS: A customized genotyping array was used to assess over 17,000 variants in coding, non-coding, regulatory, and known susceptibility regions in 4,973 EOC cases and 5,640 controls from 13 independent studies. Susceptibility for EOC overall and for select histotypes was evaluated using logistic regression adjusted for age, study site, and population substructure. CONCLUSION: Given the novel variants identified within the 2q31, 3q25, 5p15, 8q21, 8q24, 10p12, 17q12, 17q21.31, and 19p13 regions, larger follow-up genotyping studies, using imputation where necessary, are needed for fine-mapping and confirmation of low frequency variants that fall below statistical significance.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 16, 2016

Volume

7

Issue

7

Start / End Page

7381 / 7389

Location

United States

Related Subject Headings

  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oligonucleotide Array Sequence Analysis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Humans
  • Genotype
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Earp, M., Winham, S. J., Larson, N., Permuth, J. B., Sicotte, H., Chien, J., … Goode, E. L. (2016). A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget, 7(7), 7381–7389. https://doi.org/10.18632/oncotarget.7121
Earp, Madalene, Stacey J. Winham, Nicholas Larson, Jennifer B. Permuth, Hugues Sicotte, Jeremy Chien, Hoda Anton-Culver, et al. “A targeted genetic association study of epithelial ovarian cancer susceptibility.Oncotarget 7, no. 7 (February 16, 2016): 7381–89. https://doi.org/10.18632/oncotarget.7121.
Earp M, Winham SJ, Larson N, Permuth JB, Sicotte H, Chien J, et al. A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget. 2016 Feb 16;7(7):7381–9.
Earp, Madalene, et al. “A targeted genetic association study of epithelial ovarian cancer susceptibility.Oncotarget, vol. 7, no. 7, Feb. 2016, pp. 7381–89. Pubmed, doi:10.18632/oncotarget.7121.
Earp M, Winham SJ, Larson N, Permuth JB, Sicotte H, Chien J, Anton-Culver H, Bandera EV, Berchuck A, Cook LS, Cramer D, Doherty JA, Goodman MT, Levine DA, Monteiro ANA, Ness RB, Pearce CL, Rossing MA, Tworoger SS, Wentzensen N, Bisogna M, Brinton L, Brooks-Wilson A, Carney ME, Cunningham JM, Edwards RP, Fogarty ZC, Iversen ES, Kraft P, Larson MC, Le ND, Lin H-Y, Lissowska J, Modugno F, Moysich KB, Olson SH, Pike MC, Poole EM, Rider DN, Terry KL, Thompson PJ, van den Berg D, Vierkant RA, Vitonis AF, Wilkens LR, Wu AH, Yang HP, Ziogas A, Phelan CM, Schildkraut JM, Chen YA, Sellers TA, Fridley BL, Goode EL. A targeted genetic association study of epithelial ovarian cancer susceptibility. Oncotarget. 2016 Feb 16;7(7):7381–7389.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 16, 2016

Volume

7

Issue

7

Start / End Page

7381 / 7389

Location

United States

Related Subject Headings

  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Oligonucleotide Array Sequence Analysis
  • Neoplasms, Glandular and Epithelial
  • Neoplasm Staging
  • Humans
  • Genotype
  • Genome-Wide Association Study