Ischemic QRS prolongation as a biomarker of severe myocardial ischemia.


Journal Article

Previous studies have shown that QRS prolongation is a sign of depressed collateral flow and increased rate of myocardial cell death during coronary occlusion. The aims of this study were to evaluate ischemic QRS prolongation as a biomarker of severe ischemia by establishing the relationship between prolongation and collateral flow experimentally in a dog model, and test if the same pattern of ischemic QRS prolongation occurs in man.Degree of ischemic QRS prolongation was measured using a novel method in dogs (n=23) and patients (n=52) during coronary occlusion for 5min. Collateral arterial flow was assessed in the dogs.There was a significant correlation between QRS prolongation and collateral flow in dogs (r=0.61, p=0.008). Magnitude and temporal evolution of prolongation during ischemia were similar for dogs and humans (p=0.202 and p=0.911).Quantification of ischemic QRS prolongation could potentially be used as a biomarker for severe myocardial ischemia.

Full Text

Cited Authors

  • Almer, J; Jennings, RB; Maan, AC; Ringborn, M; Maynard, C; Pahlm, O; Arheden, H; Wagner, GS; Engblom, H

Published Date

  • March 2016

Published In

Volume / Issue

  • 49 / 2

Start / End Page

  • 139 - 147

PubMed ID

  • 26810927

Pubmed Central ID

  • 26810927

Electronic International Standard Serial Number (EISSN)

  • 1532-8430

International Standard Serial Number (ISSN)

  • 0022-0736

Digital Object Identifier (DOI)

  • 10.1016/j.jelectrocard.2015.12.010


  • eng