PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.

Journal Article (Journal Article)

The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74). The results were further validated by a meta-analysis. In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. However, large and well-designed studies are warranted to validate our findings.

Full Text

Duke Authors

Cited Authors

  • Qiu, L-X; Cheng, L; He, J; Zhou, Z-R; Wang, M-Y; Zhou, F; Guo, W-J; Li, J; Sun, M-H; Zhou, X-Y; Wang, Y-N; Yang, Y-J; Wang, J-C; Jin, L; Zhu, X-D; Wei, Q-Y

Published Date

  • February 23, 2016

Published In

Volume / Issue

  • 7 / 8

Start / End Page

  • 9420 - 9428

PubMed ID

  • 26848528

Pubmed Central ID

  • PMC4891049

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.7137


  • eng

Conference Location

  • United States