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PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.

Publication ,  Journal Article
Qiu, L-X; Cheng, L; He, J; Zhou, Z-R; Wang, M-Y; Zhou, F; Guo, W-J; Li, J; Sun, M-H; Zhou, X-Y; Wang, Y-N; Yang, Y-J; Wang, J-C; Jin, L ...
Published in: Oncotarget
February 23, 2016

The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. The associations between the PSCA rs2294008 and rs2976392 single nucleotide polymorphisms (SNPs) and gastric cancer (GCa) susceptibility were still controversial. To derive a more precise estimation of the associations, we conducted a case-control study of 1,124 cases and 1,192 controls in an eastern Chinese population. We found that the rs2294008T variant genotypes were associated with an increased GCa risk in this study population (CT vs CC, OR=1.59, 95% CI=1.33-1.89 and CT+TT vs CC, OR=1.38, 95% CI=1.17-1.62). For SNP rs2976392, the variant A genotypes were also associated with an increased GCa risk (AG vs GG, OR=1.61, 95% CI=1.35-1.91 and AG+AA vs GG, OR=1.47, 95% CI=1.25-1.74). The results were further validated by a meta-analysis. In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. However, large and well-designed studies are warranted to validate our findings.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 23, 2016

Volume

7

Issue

8

Start / End Page

9420 / 9428

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Prostate-Specific Antigen
  • Polymorphism, Single Nucleotide
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Gene Frequency
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Qiu, L.-X., Cheng, L., He, J., Zhou, Z.-R., Wang, M.-Y., Zhou, F., … Wei, Q.-Y. (2016). PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. Oncotarget, 7(8), 9420–9428. https://doi.org/10.18632/oncotarget.7137
Qiu, Li-Xin, Lei Cheng, Jing He, Zhi-Rui Zhou, Meng-Yun Wang, Fei Zhou, Wei-Jian Guo, et al. “PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.Oncotarget 7, no. 8 (February 23, 2016): 9420–28. https://doi.org/10.18632/oncotarget.7137.
Qiu L-X, Cheng L, He J, Zhou Z-R, Wang M-Y, Zhou F, et al. PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. Oncotarget. 2016 Feb 23;7(8):9420–8.
Qiu, Li-Xin, et al. “PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.Oncotarget, vol. 7, no. 8, Feb. 2016, pp. 9420–28. Pubmed, doi:10.18632/oncotarget.7137.
Qiu L-X, Cheng L, He J, Zhou Z-R, Wang M-Y, Zhou F, Guo W-J, Li J, Sun M-H, Zhou X-Y, Wang Y-N, Yang Y-J, Wang J-C, Jin L, Zhu X-D, Wei Q-Y. PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population. Oncotarget. 2016 Feb 23;7(8):9420–9428.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 23, 2016

Volume

7

Issue

8

Start / End Page

9420 / 9428

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Prostate-Specific Antigen
  • Polymorphism, Single Nucleotide
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Gene Frequency