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APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.

Publication ,  Journal Article
Taylor, WD; Boyd, B; Turner, R; McQuoid, DR; Ashley-Koch, A; MacFall, JR; Saleh, A; Potter, GG
Published in: Brain Imaging Behav
February 2017

The APOE ε4 allele is associated with cognitive deficits and brain atrophy in older adults, but studies in younger adults are mixed. We examined APOE genotype effects on cognition and brain structure in younger adults and whether genotype effects differed by age and with presence of depression. 157 adults (32 % ε4 carriers, 46 % depressed) between 20 and 50 years of age completed neuropsychological testing, 131 of which also completed 3 T cranial MRI. We did not observe a direct effect of APOE genotype on cognitive performance or structural MRI measures. A significant genotype by age interaction was observed for executive function, where age had less of an effect on executive function in ε4 carriers. Similar interactions were observed for the entorhinal cortex, rostral and caudal anterior cingulate cortex and parahippocampal gyrus, where the effect of age on regional volumes was reduced in ε4 carriers. There were no significant interactions between APOE genotype and depression diagnosis. The ε4 allele benefits younger adults by allowing them to maintain executive function performance and volumes of cingulate and temporal cortex regions with aging, at least through age fifty years.

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Published In

Brain Imaging Behav

DOI

EISSN

1931-7565

Publication Date

February 2017

Volume

11

Issue

1

Start / End Page

194 / 204

Location

United States

Related Subject Headings

  • Young Adult
  • Temporal Lobe
  • Organ Size
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Heterozygote
  • Gyrus Cinguli
 

Citation

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Taylor, W. D., Boyd, B., Turner, R., McQuoid, D. R., Ashley-Koch, A., MacFall, J. R., … Potter, G. G. (2017). APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults. Brain Imaging Behav, 11(1), 194–204. https://doi.org/10.1007/s11682-016-9522-9
Taylor, Warren D., Brian Boyd, Rachel Turner, Douglas R. McQuoid, Allison Ashley-Koch, James R. MacFall, Ayman Saleh, and Guy G. Potter. “APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.Brain Imaging Behav 11, no. 1 (February 2017): 194–204. https://doi.org/10.1007/s11682-016-9522-9.
Taylor WD, Boyd B, Turner R, McQuoid DR, Ashley-Koch A, MacFall JR, et al. APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults. Brain Imaging Behav. 2017 Feb;11(1):194–204.
Taylor, Warren D., et al. “APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults.Brain Imaging Behav, vol. 11, no. 1, Feb. 2017, pp. 194–204. Pubmed, doi:10.1007/s11682-016-9522-9.
Taylor WD, Boyd B, Turner R, McQuoid DR, Ashley-Koch A, MacFall JR, Saleh A, Potter GG. APOE ε4 associated with preserved executive function performance and maintenance of temporal and cingulate brain volumes in younger adults. Brain Imaging Behav. 2017 Feb;11(1):194–204.
Journal cover image

Published In

Brain Imaging Behav

DOI

EISSN

1931-7565

Publication Date

February 2017

Volume

11

Issue

1

Start / End Page

194 / 204

Location

United States

Related Subject Headings

  • Young Adult
  • Temporal Lobe
  • Organ Size
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Heterozygote
  • Gyrus Cinguli