Copper-catalyzed intermolecular oxyamination of olefins using carboxylic acids and O-benzoylhydroxylamines.

Journal Article (letter;Journal Article)

This paper reports a novel approach for the direct and facile synthesis of 1,2-oxyamino moieties via an intermolecular copper-catalyzed oxyamination of olefins. This strategy utilizes O-benzoylhydroxylamines as an electrophilic amine source and carboxylic acids as a nucleophilic oxygen source to achieve a modular difunctionalization of olefins. The reaction proceeded in a regioselective manner with moderate to good yields, exhibiting a broad scope of carboxylic acid, amine, and olefin substrates.

Full Text

Duke Authors

Cited Authors

  • Hemric, BN; Wang, Q

Published Date

  • January 7, 2016

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 22 - 28

PubMed ID

  • 26877805

Pubmed Central ID

  • PMC4734347

Electronic International Standard Serial Number (EISSN)

  • 1860-5397

International Standard Serial Number (ISSN)

  • 1860-5397

Digital Object Identifier (DOI)

  • 10.3762/bjoc.12.4


  • eng