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A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

Publication ,  Journal Article
Wang, M-Y; He, J; Zhu, M-L; Teng, X-Y; Li, Q-X; Sun, M-H; Wang, X-F; Yang, Y-J; Wang, J-C; Jin, L; Wang, Y-N; Wei, Q-Y
Published in: Sci Rep
January 28, 2016

AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free controls. We genotyped five SNPs (AKT1 rs2494750G >C, AKT1 rs2494752A >G, AKT1 rs10138227C >T, AKT2 rs7254617G>A and AKT2 rs2304186G >T) located in the 5' upstream regulatory, first intron or promoter regions. In the logistic regression analysis, a significantly elevated GCa risk was associated with the rs2494752 AG/GG variant genotypes (adjusted odds ratio [OR] = 1.20, 95% confidence interval [CI] = 1.02-1.42) under a dominant genetic model, and this risk was more evident in subgroups of ever drinkers. The luciferase reporter assay showed that the rs2494752 G allele significantly increased luciferase activity. Our results suggest that the potentially functional AKT1 rs2494752 SNP may affect GCa susceptibility, likely by modulating the AKT1 promoter transcriptional activity. Larger, independent studies are warranted to validate our findings.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 28, 2016

Volume

6

Start / End Page

20008

Location

England

Related Subject Headings

  • Young Adult
  • Transcription, Genetic
  • Stomach Neoplasms
  • Risk Factors
  • Proto-Oncogene Proteins c-akt
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Neoplasm Staging
  • Middle Aged
  • Male
 

Citation

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Wang, M.-Y., He, J., Zhu, M.-L., Teng, X.-Y., Li, Q.-X., Sun, M.-H., … Wei, Q.-Y. (2016). A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. Sci Rep, 6, 20008. https://doi.org/10.1038/srep20008
Wang, Meng-Yun, Jing He, Mei-Ling Zhu, Xiao-Yan Teng, Qiao-Xin Li, Meng-Hong Sun, Xiao-Feng Wang, et al. “A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.Sci Rep 6 (January 28, 2016): 20008. https://doi.org/10.1038/srep20008.
Wang M-Y, He J, Zhu M-L, Teng X-Y, Li Q-X, Sun M-H, et al. A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. Sci Rep. 2016 Jan 28;6:20008.
Wang, Meng-Yun, et al. “A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.Sci Rep, vol. 6, Jan. 2016, p. 20008. Pubmed, doi:10.1038/srep20008.
Wang M-Y, He J, Zhu M-L, Teng X-Y, Li Q-X, Sun M-H, Wang X-F, Yang Y-J, Wang J-C, Jin L, Wang Y-N, Wei Q-Y. A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. Sci Rep. 2016 Jan 28;6:20008.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 28, 2016

Volume

6

Start / End Page

20008

Location

England

Related Subject Headings

  • Young Adult
  • Transcription, Genetic
  • Stomach Neoplasms
  • Risk Factors
  • Proto-Oncogene Proteins c-akt
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Neoplasm Staging
  • Middle Aged
  • Male