Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.

Published

Journal Article

Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically significant. We use high-resolution, active, flexible surface electrode arrays with 500 μm inter-electrode spacing to explore epileptiform local field potential (LFP) spike propagation patterns in two dimensions recorded from subdural micro-electrocorticographic signals in vivo in cat. In this study, we aimed to develop methods to quantitatively characterize the spatiotemporal dynamics of epileptiform activity at high-resolution.We topically administered a GABA-antagonist, picrotoxin, to induce acute neocortical epileptiform activity leading up to discrete electrographic seizures. We extracted features from LFP spikes to characterize spatiotemporal patterns in these events. We then tested the hypothesis that two-dimensional spike patterns during seizures were different from those between seizures.We showed that spatially correlated events can be used to distinguish ictal versus interictal spikes.We conclude that sub-millimeter-scale spatiotemporal spike patterns reveal network dynamics that are invisible to standard clinical recordings and contain information related to seizure-state.

Full Text

Duke Authors

Cited Authors

  • Vanleer, AC; Blanco, JA; Wagenaar, JB; Viventi, J; Contreras, D; Litt, B

Published Date

  • April 2016

Published In

Volume / Issue

  • 13 / 2

Start / End Page

  • 026015 -

PubMed ID

  • 26859260

Pubmed Central ID

  • 26859260

Electronic International Standard Serial Number (EISSN)

  • 1741-2552

International Standard Serial Number (ISSN)

  • 1741-2560

Digital Object Identifier (DOI)

  • 10.1088/1741-2560/13/2/026015

Language

  • eng