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Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.

Publication ,  Journal Article
Vanleer, AC; Blanco, JA; Wagenaar, JB; Viventi, J; Contreras, D; Litt, B
Published in: Journal of neural engineering
April 2016

Current mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale domains have a role in seizure generation that may be clinically significant. We use high-resolution, active, flexible surface electrode arrays with 500 μm inter-electrode spacing to explore epileptiform local field potential (LFP) spike propagation patterns in two dimensions recorded from subdural micro-electrocorticographic signals in vivo in cat. In this study, we aimed to develop methods to quantitatively characterize the spatiotemporal dynamics of epileptiform activity at high-resolution.We topically administered a GABA-antagonist, picrotoxin, to induce acute neocortical epileptiform activity leading up to discrete electrographic seizures. We extracted features from LFP spikes to characterize spatiotemporal patterns in these events. We then tested the hypothesis that two-dimensional spike patterns during seizures were different from those between seizures.We showed that spatially correlated events can be used to distinguish ictal versus interictal spikes.We conclude that sub-millimeter-scale spatiotemporal spike patterns reveal network dynamics that are invisible to standard clinical recordings and contain information related to seizure-state.

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Published In

Journal of neural engineering

DOI

EISSN

1741-2552

ISSN

1741-2560

Publication Date

April 2016

Volume

13

Issue

2

Start / End Page

026015

Related Subject Headings

  • Seizures
  • Electroencephalography
  • Electrodes, Implanted
  • Cats
  • Biomedical Engineering
  • Animals
  • Action Potentials
  • 4003 Biomedical engineering
  • 3209 Neurosciences
  • 1109 Neurosciences
 

Citation

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ICMJE
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Vanleer, A. C., Blanco, J. A., Wagenaar, J. B., Viventi, J., Contreras, D., & Litt, B. (2016). Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures. Journal of Neural Engineering, 13(2), 026015. https://doi.org/10.1088/1741-2560/13/2/026015
Vanleer, Ann C., Justin A. Blanco, Joost B. Wagenaar, Jonathan Viventi, Diego Contreras, and Brian Litt. “Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.Journal of Neural Engineering 13, no. 2 (April 2016): 026015. https://doi.org/10.1088/1741-2560/13/2/026015.
Vanleer AC, Blanco JA, Wagenaar JB, Viventi J, Contreras D, Litt B. Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures. Journal of neural engineering. 2016 Apr;13(2):026015.
Vanleer, Ann C., et al. “Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.Journal of Neural Engineering, vol. 13, no. 2, Apr. 2016, p. 026015. Epmc, doi:10.1088/1741-2560/13/2/026015.
Vanleer AC, Blanco JA, Wagenaar JB, Viventi J, Contreras D, Litt B. Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures. Journal of neural engineering. 2016 Apr;13(2):026015.
Journal cover image

Published In

Journal of neural engineering

DOI

EISSN

1741-2552

ISSN

1741-2560

Publication Date

April 2016

Volume

13

Issue

2

Start / End Page

026015

Related Subject Headings

  • Seizures
  • Electroencephalography
  • Electrodes, Implanted
  • Cats
  • Biomedical Engineering
  • Animals
  • Action Potentials
  • 4003 Biomedical engineering
  • 3209 Neurosciences
  • 1109 Neurosciences