A case report - Volatile metabolomic signature of malignant melanoma using matching skin as a control.

Journal Article (Journal Article)

Melanoma is the most serious form of skin cancer. The quest for melanoma diagnostic biomarkers is paramount since early detection of melanoma and surgical excision represent the only effective treatment of this capricious disease. Our recent study tested the hypothesis that melanoma forms a unique volatile signature that is different than control, healthy tissue. Here, we are reporting a case study, the analysis of the volatile metabolic signature of a malignant melanoma using matched, non-neoplastic skin tissue from the same patient as a control. This is a significant improvement in the methodology, since it is well known that diet, skin type, genetic background, age, sex and environment all contribute to individual variation in the skin volatile signature. In the present study, we have identified 32 volatile compounds; 9 volatile compounds were increased in melanoma when compared to normal skin and 23 volatile compounds were detected only in melanoma and not in normal skin. Out of these 32 compounds, 10 have been reported previously by our group, thus confirming our results and adding additional confidence in our untargeted metabolomics approach for detection of melanoma biomarkers.

Full Text

Duke Authors

Cited Authors

  • Abaffy, T; Möller, M; Riemer, DD; Milikowski, C; Defazio, RA

Published Date

  • 2011

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 140 - 144

PubMed ID

  • 22229073

Pubmed Central ID

  • PMC3251165

International Standard Serial Number (ISSN)

  • 1948-5956

Digital Object Identifier (DOI)

  • 10.4172/1948-5956.1000076

Language

  • eng

Conference Location

  • United States