Troponin T and serum enzymes in monitoring open heart surgery
The values of Troponin T (TnT), a structurally bound protein found in striated muscle cells, and of a group of enzymes were investigated as diagnostic criteria for acute myocardial infarction (AMI) following open heart surgery. In 16 patients subjected to open heart surgery, peripheral venous blood was collected over 5-70 h after surgery. TnT was measured by an enzyme immunoassay (Elisa, Boehringer Mannheim), CK-MB by the immunoinhibition method (Boehringer Mannheim), and total CK, LDH and AST were measured by standard spectrophotometric methods (Herbos, Sisak). The values of CK, LDH and AST were significantly above the reference range (p<0.05) throughout the measurement, while the CK-MB values were rather inconsistent, sometimes significantly above and sometimes close to the upper reference limit. The TnT values were always slightly above the upper reference limit, but this increase was not statistically significant (p<0.05). Since the outcome of open heart surgery in the patients was good, the data suggest that the enzyme pattern, being a consequence of abundant enzyme release from the heart tissue and blood cells during the surgery itself, cannot be taken as a reliable diagnostic parameter for AIM. TnT, with its slight increase, could be used as a sensitive and reliable parameter in monitoring the outcome of open heart surgery.
Topic, E; Zovko, V; Abaffy, T; Barbaric, V; Rudez, I; Jelic, I
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