Antiplatelet Therapy in Percutaneous Coronary Intervention.


Journal Article (Review)

Platelets play a key role in mediating stent thrombosis, which is the major cause of ischemic events immediately after percutaneous coronary intervention (PCI). Antiplatelet therapy is therefore the cornerstone of antithrombotic therapy after PCI. However, the use of antiplatelet agents increases bleeding risk, with more potent antiplatelet agents further increasing bleeding risk. In the past 5 years, potent and fast-acting P2Y12 inhibitors have augmented the antiplatelet armamentarium available to interventional cardiologists. This article reviews the preclinical and clinical data surrounding these new agents, and discusses the significant questions and controversies that still exist regarding the optimal antiplatelet strategy.

Full Text

Duke Authors

Cited Authors

  • Fanaroff, AC; Rao, SV

Published Date

  • April 2016

Published In

  • Interv Cardiol Clin

Volume / Issue

  • 5 / 2

Start / End Page

  • 221 - 237

PubMed ID

  • 28582206

Pubmed Central ID

  • 28582206

Electronic International Standard Serial Number (EISSN)

  • 2211-7466

Digital Object Identifier (DOI)

  • 10.1016/j.iccl.2015.12.007


  • eng

Conference Location

  • Netherlands