Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.

Journal Article (Journal Article)

The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics approaches to define proteins with altered abundance during protein kinase A (PKA) activation and repression in the opportunistic human fungal pathogen Cryptococcus neoformans. They observed an association between microbial PKA signaling and ubiquitin-proteasome regulation of protein homeostasis. Additionally, they correlated these processes with expression of polysaccharide capsule on the fungal cell surface, the main virulence-associated phenotype in this organism. Not only are their findings important for microbial pathogenesis, but they also support similar associations between human PKA signaling and ubiquitinated protein accumulation in neurodegenerative diseases.

Full Text

Duke Authors

Cited Authors

  • Alspaugh, JA

Published Date

  • February 9, 2016

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • e00021 - e00016

PubMed ID

  • 26861014

Pubmed Central ID

  • PMC4752596

Electronic International Standard Serial Number (EISSN)

  • 2150-7511

Digital Object Identifier (DOI)

  • 10.1128/mBio.00021-16


  • eng

Conference Location

  • United States