Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.

Journal Article (Review)

In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.

Full Text

Duke Authors

Cited Authors

  • Hodgkinson, CP; Bareja, A; Gomez, JA; Dzau, VJ

Published Date

  • January 2016

Published In

Volume / Issue

  • 118 / 1

Start / End Page

  • 95 - 107

PubMed ID

  • 26837742

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

International Standard Serial Number (ISSN)

  • 0009-7330

Digital Object Identifier (DOI)

  • 10.1161/circresaha.115.305373

Language

  • eng