Journal Article (Journal Article;Review)

Cryptococcosis is an invasive mycosis caused by pathogenic encapsulated yeasts in the genus Cryptococcus. Cryptococcus gained prominence as a pathogen capable of widespread disease outbreaks in vulnerable populations. We have gained insight into the pathobiology of Cryptococcus, including the yeast' s capacity to adapt to environmental pressures, exploit new geographic environments, and cause disease in both immunocompromised and apparently immunocompetent hosts. Inexpensive, point-of-care testing makes diagnosis more feasible than ever. The associated worldwide burden and mortality remains unacceptably high. Novel screening strategies and preemptive therapy offer promise at making a sustained and much needed impact on this sugar-coated opportunistic mycosis.

Full Text

Duke Authors

Cited Authors

  • Maziarz, EK; Perfect, JR

Published Date

  • March 2016

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 179 - 206

PubMed ID

  • 26897067

Pubmed Central ID

  • PMC5808417

Electronic International Standard Serial Number (EISSN)

  • 1557-9824

Digital Object Identifier (DOI)

  • 10.1016/j.idc.2015.10.006


  • eng

Conference Location

  • United States